Comparing poor and favorable outcome prediction with machine learning after mechanical thrombectomy in acute ischemic stroke
Background and PurposeOutcome prediction after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) and large vessel occlusion (LVO) is commonly performed by focusing on favorable outcome (modified Rankin Scale, mRS 0-2) after 3 months but poor outcome representing severe disabi...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 May 2022
|
| In: |
Frontiers in neurology
Year: 2022, Volume: 13, Pages: 1-11 |
| ISSN: | 1664-2295 |
| Online Access: | Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fneur.2022.737667
|
| Author Notes: | Matthias A. Mutke, Vince I. Madai, Adam Hilbert, Esra Zihni, Arne Potreck, Charlotte S. Weyland, Markus A. Möhlenbruch, Sabine Heiland, Peter A. Ringleb, Simon Nagel, Martin Bendszus and Dietmar Frey |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1809305136 | ||
| 003 | DE-627 | ||
| 005 | 20220927110434.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220706s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fneur.2022.737667 |2 doi | |
| 035 | |a (DE-627)1809305136 | ||
| 035 | |a (DE-599)KXP1809305136 | ||
| 035 | |a (OCoLC)1341463506 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mutke, Matthias Anthony |d 1987- |e VerfasserIn |0 (DE-588)1126261769 |0 (DE-627)88085622X |0 (DE-576)484425633 |4 aut | |
| 245 | 1 | 0 | |a Comparing poor and favorable outcome prediction with machine learning after mechanical thrombectomy in acute ischemic stroke |c Matthias A. Mutke, Vince I. Madai, Adam Hilbert, Esra Zihni, Arne Potreck, Charlotte S. Weyland, Markus A. Möhlenbruch, Sabine Heiland, Peter A. Ringleb, Simon Nagel, Martin Bendszus and Dietmar Frey |
| 264 | 1 | |c 27 May 2022 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.07.2022 | ||
| 520 | |a Background and PurposeOutcome prediction after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) and large vessel occlusion (LVO) is commonly performed by focusing on favorable outcome (modified Rankin Scale, mRS 0-2) after 3 months but poor outcome representing severe disability and mortality (mRS 5 and 6) might be of equal importance for clinical decision-making.MethodsWe retrospectively analyzed patients with AIS and LVO undergoing MT from 2009 to 2018. Prognostic variables were grouped in baseline clinical (A), MRI-derived variables including mismatch [apparent diffusion coefficient (ADC) and time-to-maximum (Tmax) lesion volume] (B), and variables reflecting speed and extent of reperfusion (C) [modified treatment in cerebral ischemia (mTICI) score and time from onset to mTICI]. Three different scenarios were analyzed: (1) baseline clinical parameters only, (2) baseline clinical and MRI-derived parameters, and (3) all baseline clinical, imaging-derived, and reperfusion-associated parameters. For each scenario, we assessed prediction for favorable and poor outcome with seven different machine learning algorithms.ResultsIn 210 patients, prediction of favorable outcome was improved after including speed and extent of recanalization [highest area under the curve (AUC) 0.73] compared to using baseline clinical variables only (highest AUC 0.67). Prediction of poor outcome remained stable by using baseline clinical variables only (highest AUC 0.71) and did not improve further by additional variables. Prediction of favorable and poor outcomes was not improved by adding MR-mismatch variables. Most important baseline clinical variables for both outcomes were age, National Institutes of Health Stroke Scale, and premorbid mRS.ConclusionsOur results suggest that a prediction of poor outcome after AIS and MT could be made based on clinical baseline variables only. Speed and extent of MT did improve prediction for a favorable outcome but is not relevant for poor outcome. An MR mismatch with small ischemic core and larger penumbral tissue showed no predictive importance. | ||
| 700 | 1 | |a Madai, Vince Istvan |e VerfasserIn |0 (DE-588)115165972X |0 (DE-627)1012141020 |0 (DE-576)497995646 |4 aut | |
| 700 | 1 | |a Hilbert, Adam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zihni, Esra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Potreck, Arne |e VerfasserIn |0 (DE-588)1031679790 |0 (DE-627)737108886 |0 (DE-576)379370638 |4 aut | |
| 700 | 1 | |a Weyland, Charlotte S. |d 1990- |e VerfasserIn |0 (DE-588)1208458426 |0 (DE-627)1694725235 |4 aut | |
| 700 | 1 | |a Möhlenbruch, Markus Alfred |d 1979- |e VerfasserIn |0 (DE-588)137693591 |0 (DE-627)594845041 |0 (DE-576)304845655 |4 aut | |
| 700 | 1 | |a Heiland, Sabine |e VerfasserIn |0 (DE-588)106732626X |0 (DE-627)818624450 |0 (DE-576)426561368 |4 aut | |
| 700 | 1 | |a Ringleb, Peter A. |e VerfasserIn |0 (DE-588)1032676175 |0 (DE-627)73863364X |0 (DE-576)172917743 |4 aut | |
| 700 | 1 | |a Nagel, Simon |d 1974- |e VerfasserIn |0 (DE-588)129036072 |0 (DE-627)38788775X |0 (DE-576)297460218 |4 aut | |
| 700 | 1 | |a Bendszus, Martin |e VerfasserIn |0 (DE-588)1032676426 |0 (DE-627)738634131 |0 (DE-576)175567697 |4 aut | |
| 700 | 1 | |a Frey, Dietmar |e VerfasserIn |0 (DE-588)1237243920 |0 (DE-627)1763184404 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in neurology |d Lausanne : Frontiers Research Foundation, 2008 |g 13(2022), Artikel-ID 737667, Seite 1-11 |h Online-Ressource |w (DE-627)631498753 |w (DE-600)2564214-5 |w (DE-576)326550933 |x 1664-2295 |7 nnas |a Comparing poor and favorable outcome prediction with machine learning after mechanical thrombectomy in acute ischemic stroke |
| 773 | 1 | 8 | |g volume:13 |g year:2022 |g elocationid:737667 |g pages:1-11 |g extent:11 |a Comparing poor and favorable outcome prediction with machine learning after mechanical thrombectomy in acute ischemic stroke |
| 856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fneur.2022.737667 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220706 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1032676426 |a Bendszus, Martin |m 1032676426:Bendszus, Martin |d 910000 |d 911100 |d 50000 |e 910000PB1032676426 |e 911100PB1032676426 |e 50000PB1032676426 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 11 | ||
| 998 | |g 129036072 |a Nagel, Simon |m 129036072:Nagel, Simon |d 910000 |d 911100 |d 50000 |e 910000PN129036072 |e 911100PN129036072 |e 50000PN129036072 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 10 | ||
| 998 | |g 1032676175 |a Ringleb, Peter A. |m 1032676175:Ringleb, Peter A. |d 910000 |d 911100 |e 910000PR1032676175 |e 911100PR1032676175 |k 0/910000/ |k 1/910000/911100/ |p 9 | ||
| 998 | |g 106732626X |a Heiland, Sabine |m 106732626X:Heiland, Sabine |d 910000 |d 911100 |d 50000 |e 910000PH106732626X |e 911100PH106732626X |e 50000PH106732626X |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 8 | ||
| 998 | |g 137693591 |a Möhlenbruch, Markus Alfred |m 137693591:Möhlenbruch, Markus Alfred |d 910000 |d 911100 |d 50000 |e 910000PM137693591 |e 911100PM137693591 |e 50000PM137693591 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 7 | ||
| 998 | |g 1208458426 |a Weyland, Charlotte S. |m 1208458426:Weyland, Charlotte S. |d 910000 |d 911100 |d 50000 |e 910000PW1208458426 |e 911100PW1208458426 |e 50000PW1208458426 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 6 | ||
| 998 | |g 1031679790 |a Potreck, Arne |m 1031679790:Potreck, Arne |d 910000 |d 911400 |e 910000PP1031679790 |e 911400PP1031679790 |k 0/910000/ |k 1/910000/911400/ |p 5 | ||
| 998 | |g 1126261769 |a Mutke, Matthias Anthony |m 1126261769:Mutke, Matthias Anthony |d 910000 |d 911100 |e 910000PM1126261769 |e 911100PM1126261769 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1809305136 |e 416188494X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 06.07.2022"],"relHost":[{"pubHistory":["2008 -"],"title":[{"title_sort":"Frontiers in neurology","title":"Frontiers in neurology"}],"part":{"text":"13(2022), Artikel-ID 737667, Seite 1-11","year":"2022","volume":"13","pages":"1-11","extent":"11"},"language":["eng"],"disp":"Comparing poor and favorable outcome prediction with machine learning after mechanical thrombectomy in acute ischemic strokeFrontiers in neurology","physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1664-2295"],"zdb":["2564214-5"],"eki":["631498753"]},"note":["Gesehen am 18.08.20","Specialty sections: Autonomic Neuroscience; Brain Imaging Methods; Dementia; Endovascular and Interventional Neurology; Epilepsy; Headache Medicine and Facial Pain; Movement Disorders; Multiple Sclerosis and Neuroimmunology; Neurocritical and Neurohospitalist; Care; Neurodegeneration; Neurogenomics; Neurology Education; Neuromuscular Diseases; Neuro-Oncology; Neuro-Ophthalmology; Neuro-Otology; Neuropediatrics; Neuropharmacology; Neuroprosthetics; Neurotrauma; Sleep and Chronobiology; Spinal Cord Medicine; Sports Neurology; Stroke; Teleneurology"],"origin":[{"publisherPlace":"Lausanne","dateIssuedDisp":"2008-","publisher":"Frontiers Research Foundation","dateIssuedKey":"2008"}],"recId":"631498753","titleAlt":[{"title":"Autonomic Neuroscience"},{"title":"Brain Imaging Methods"},{"title":"Dementia"},{"title":"Endovascular and Interventional Neurology"},{"title":"Epilepsy"},{"title":"Headache Medicine and Facial Pain"},{"title":"Movement Disorders"},{"title":"Multiple Sclerosis and Neuroimmunology"},{"title":"Neurocritical and Neurohospitalist Care"},{"title":"Neurodegeneration"},{"title":"Neurogenomics"},{"title":"Neurology Education"},{"title":"Neuromuscular Diseases"},{"title":"Neuro-Oncology"},{"title":"Neuro-Ophthalmology"},{"title":"Neuro-Otology"},{"title":"Neuropediatrics"},{"title":"Neuropharmacology"},{"title":"Neuroprosthetics"},{"title":"Neurotrauma"},{"title":"Sleep and Chronobiology"},{"title":"Spinal Cord Medicine"},{"title":"Sports Neurology"},{"title":"Stroke"},{"title":"Teleneurology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"name":{"displayForm":["Frontiers Research Foundation"]}}],"id":{"doi":["10.3389/fneur.2022.737667"],"eki":["1809305136"]},"physDesc":[{"extent":"11 S."}],"recId":"1809305136","origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"27 May 2022"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"family":"Mutke","role":"aut","given":"Matthias Anthony","display":"Mutke, Matthias Anthony"},{"family":"Madai","given":"Vince Istvan","role":"aut","display":"Madai, Vince Istvan"},{"family":"Hilbert","display":"Hilbert, Adam","given":"Adam","role":"aut"},{"family":"Zihni","display":"Zihni, Esra","role":"aut","given":"Esra"},{"family":"Potreck","given":"Arne","role":"aut","display":"Potreck, Arne"},{"given":"Charlotte S.","role":"aut","display":"Weyland, Charlotte S.","family":"Weyland"},{"family":"Möhlenbruch","display":"Möhlenbruch, Markus Alfred","role":"aut","given":"Markus Alfred"},{"given":"Sabine","role":"aut","display":"Heiland, Sabine","family":"Heiland"},{"display":"Ringleb, Peter A.","given":"Peter A.","role":"aut","family":"Ringleb"},{"family":"Nagel","display":"Nagel, Simon","role":"aut","given":"Simon"},{"role":"aut","given":"Martin","display":"Bendszus, Martin","family":"Bendszus"},{"family":"Frey","display":"Frey, Dietmar","given":"Dietmar","role":"aut"}],"name":{"displayForm":["Matthias A. Mutke, Vince I. Madai, Adam Hilbert, Esra Zihni, Arne Potreck, Charlotte S. Weyland, Markus A. Möhlenbruch, Sabine Heiland, Peter A. Ringleb, Simon Nagel, Martin Bendszus and Dietmar Frey"]},"language":["eng"],"title":[{"title":"Comparing poor and favorable outcome prediction with machine learning after mechanical thrombectomy in acute ischemic stroke","title_sort":"Comparing poor and favorable outcome prediction with machine learning after mechanical thrombectomy in acute ischemic stroke"}]} | ||
| SRT | |a MUTKEMATTHCOMPARINGP2720 | ||