A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease

Background— - - eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). - - Methods and Results—...

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Main Authors:	Wild, Philipp (Author) , Zeller, Tanja (Author) , Schillert, Arne (Author) , Szymczak, Silke (Author) , Sinning, Christoph R. (Author) , Deiseroth, Arne (Author) , Schnabel, Renate B. (Author) , Lubos, Edith (Author) , Keller, Till (Author) , Eleftheriadis, Medea S. (Author) , Bickel, Christoph (Author) , Rupprecht, Hans J. (Author) , Wilde, Sandra (Author) , Rossmann, Heidi (Author) , Diemert, Patrick (Author) , Cupples, L. Adrienne (Author) , Perret, Claire (Author) , Erdmann, Jeanette (Author) , Stark, Klaus (Author) , Kleber, Marcus E. (Author) , Epstein, Stephen E. (Author) , Voight, Benjamin F. (Author) , Kuulasmaa, Kari (Author) , Li, Mingyao (Author) , Schäfer, Arne S. (Author) , Klopp, Norman (Author) , Braund, Peter S. (Author) , Sager, Hendrik B. (Author) , Demissie, Serkalem (Author) , Proust, Carole (Author) , König, Inke R. (Author) , Wichmann, Heinz-Erich (Author) , Reinhard, Wibke (Author) , Hoffmann, Michael M. (Author) , Virtamo, Jarmo (Author) , Burnett, Mary Susan (Author) , Siscovick, David (Author) , Wiklund, Per Gunnar (Author) , Qu, Liming (Author) , El Mokthari, Nour Eddine (Author) , Thompson, John R. (Author) , Peters, Annette (Author) , Smith, Albert V. (Author) , Yon, Emmanuelle (Author) , Baumert, Jens (Author) , Hengstenberg, Christian (Author) , März, Winfried (Author) , Amouyel, Philippe (Author) , Devaney, Joseph (Author) , Schwartz, Stephen M. (Author) , Saarela, Olli (Author) , Mehta, Nehal N. (Author) , Rubin, Diana (Author) , Silander, Kaisa (Author) , Hall, Alistair S. (Author) , Ferrieres, Jean (Author) , Harris, Tamara B. (Author) , Melander, Olle (Author) , Kee, Frank (Author) , Hakonarson, Hakon (Author) , Schrezenmeir, Juergen (Author) , Gudnason, Vilmundur (Author) , Elosua, Roberto (Author) , Arveiler, Dominique (Author) , Evans, Alun (Author) , Rader, Daniel J. (Author) , Illig, Thomas (Author) , Schreiber, Stefan (Author) , Bis, Joshua C. (Author) , Altshuler, David (Author) , Kavousi, Maryam (Author) , Witteman, Jaqueline C.M. (Author) , Uitterlinden, Andre G. (Author) , Hofman, Albert (Author) , Folsom, Aaron R. (Author) , Barbalic, Maja (Author) , Boerwinkle, Eric (Author) , Kathiresan, Sekar (Author) , Reilly, Muredach P. (Author) , O'Donnell, Christopher J. (Author) , Samani, Nilesh J. (Author) , Schunkert, Heribert (Author) , Cambien, Francois (Author) , Lackner, Karl J. (Author) , Tiret, Laurence (Author) , Salomaa, Veikko (Author) , Munzel, Thomas (Author) , Ziegler, Andreas (Author) , Blankenberg, Stefan (Author)
Format:	Article (Journal)
Language:	English
Published:	August 2011
In:	Circulation. Cardiovascular genetics Year: 2011, Volume: 4, Issue: 4, Pages: 403-412
ISSN:	1942-3268
DOI:	10.1161/CIRCGENETICS.110.958728
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCGENETICS.110.958728 Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.110.958728
Author Notes:	Philipp S Wild, MD, Tanja Zeller, PhD, Arne Schillert, PhD, Silke Szymczak, PhD, Christoph R Sinning, MD, Arne Deiseroth, cand med, Renate B Schnabel, MD, MSc, Edith Lubos, MD, Till Keller, MD, Medea S Eleftheriadis, MD, Christoph Bickel, MD, Hans J Rupprecht, MD, Sandra Wilde, BA, Heidi Rossmann, MD, Patrick Diemert, MD, L Adrienne Cupples, PhD, Claire Perret, MSc, Jeanette Erdmann, PhD, Klaus Stark, PhD, Marcus E Kleber, PhD, Stephen E Epstein, MD, Benjamin F Voight, MD, Kari Kuulasmaa, PhD, Mingyao Li, PhD, Arne S Schäfer, PhD, Norman Klopp, PhD, Peter S Braund, MD, Hendrik B Sager, MD, Serkalem Demissie, MD, Carole Proust, BSc, Inke R König, PhD, Heinz-Erich Wichmann, MD, Wibke Reinhard, MD, Michael M Hoffmann, PhD, Jarmo Virtamo, MD, Mary Susan Burnett, PhD, David Siscovick, MD, Per Gunnar Wiklund, MD, Liming Qu, PhD, Nour Eddine El Mokthari, MD, John R Thompson, MD, Annette Peters, PhD, Albert V Smith, MD, Emmanuelle Yon, BSc, Jens Baumert, PhD, Christian Hengstenberg, MD, Winfried März, MD, Philippe Amouyel, MD, Joseph Devaney, MD, Stephen M Schwartz, MD, Olli Saarela, PhD, Nehal N Mehta, MD, Diana Rubin, MD, Kaisa Silander, PhD, Alistair S Hall, MD, Jean Ferrieres, MD, Tamara B Harris, MD, Olle Melander, MD, Frank Kee, MD, Hakon Hakonarson, MD, Juergen Schrezenmeir, MD, Vilmundur Gudnason, MD, Roberto Elosua, MD, Dominique Arveiler, MD, Alun Evans, MD, Daniel J Rader, MD, Thomas Illig, PhD, Stefan Schreiber, MD, Joshua C Bis, MD, David Altshuler, PhD, Maryam Kavousi, PhD, Jaqueline CM Witteman, PhD, Andre G Uitterlinden, PhD, Albert Hofman, PhD, Aaron R Folsom, MD, Maja Barbalic, PhD, Eric Boerwinkle, PhD, Sekar Kathiresan, MD, Muredach P Reilly, MD, Christopher J O'Donnell, MD, Nilesh J Samani, MD, Heribert Schunkert, MD, Francois Cambien, MD, Karl J Lackner, MD, Laurence Tiret, PhD, Veikko Salomaa, MD, Thomas Munzel, MD, Andreas Ziegler, PhD, and Stefan Blankenberg, MD