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Severe right ventricular outflow tract obstruction caused by non-hodgkin lymphoma: complete regression after one course of bendamustine/rituximab therapy

We present the case of a 67-year-old woman presenting with symptoms of predominantly right heart failure caused by cardiac tumor infiltration. Echocardiography showed almost complete obstruction, particularly of the right ventricular outflow tract. After complete diagnostic workup, treatment with on...

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Bibliographische Detailangaben
Hauptverfasser: Konstandin, Mathias (VerfasserIn) , Korosoglou, Grigorios (VerfasserIn) , Hosch, Waldemar P. (VerfasserIn) , Hardt, Stefan (VerfasserIn) , Katus, Hugo (VerfasserIn) , Mereles, Derliz (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2011
In: Journal of the American Society of Echocardiography
Year: 2011, Jahrgang: 24, Heft: 7, Pages: 818.e1-818.e4
ISSN:1097-6795
DOI:10.1016/j.echo.2010.09.005
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.echo.2010.09.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0894731710007996
Volltext
Verfasserangaben:Mathias H. Konstandin, Grigorios Korosoglou, Waldemar Hosch, Stefan E. Hardt, Hugo A. Katus, and Derliz Mereles

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520 |a We present the case of a 67-year-old woman presenting with symptoms of predominantly right heart failure caused by cardiac tumor infiltration. Echocardiography showed almost complete obstruction, particularly of the right ventricular outflow tract. After complete diagnostic workup, treatment with only one course of bendamustine and rituximab resulted in complete resolution of the obstruction. Right ventricular outflow tract restriction due to infiltrative large B-cell lymphoma is a rare finding. Compression of the heart and great vessels, such as by mediastinal tumors, is not as rare. Prompt and accurate diagnosis by echocardiography and immediate initiation of treatment can be lifesaving. 
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