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Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey

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Objective: The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. - Methods: An internat...

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Hauptverfasser: Kamisawa, Terumi (VerfasserIn) , Chari, Suresh T. (VerfasserIn) , Giday, Samuel A. (VerfasserIn) , Kim, Myung-Hwan (VerfasserIn) , Chung, Jae Bock (VerfasserIn) , Lee, Kyu Taek (VerfasserIn) , Werner, Jens (VerfasserIn) , Bergmann, Frank (VerfasserIn) , Lerch, Markus M. (VerfasserIn) , Mayerle, Julia (VerfasserIn) , Pickartz, Tilman (VerfasserIn) , Lohr, Matthias (VerfasserIn) , Schneider, Alexander (VerfasserIn) , Frulloni, Luca (VerfasserIn) , Webster, George J. M. (VerfasserIn) , Reddy, D. Nageshwar (VerfasserIn) , Liao, Wei-Chih (VerfasserIn) , Wang, Hsiu-Po (VerfasserIn) , Okazaki, Kazuichi (VerfasserIn) , Shimosegawa, Tooru (VerfasserIn) , Kloeppel, Guenter (VerfasserIn) , Go, Vay Liang W. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 2011
In: Pancreas
Year: 2011, Jahrgang: 40, Heft: 6, Pages: 809-814
ISSN:1536-4828
DOI:10.1097/MPA.0b013e3182258a15
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MPA.0b013e3182258a15
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/pancreasjournal/Fulltext/2011/08000/Clinical_Profile_of_Autoimmune_Pancreatitis_and.2.aspx
Volltext
Verfasserangaben:Terumi Kamisawa, Suresh T. Chari, Samuel A. Giday, Myung-Hwan Kim, Jae Bock Chung, Kyu Taek Lee, Jens Werner, Frank Bergmann, Markus M. Lerch, Julia Mayerle, Tilman Pickartz, Matthias Lohr, Alexander Schneider, Luca Frulloni, George J. M. Webster, D. Nageshwar Reddy, Wei-Chih Liao, Hsiu-Po Wang, Kazuichi Okazaki, Tooru Shimosegawa, Guenter Kloeppel, and Vay Liang W. Go
Beschreibung
Zusammenfassung:Objective: The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. - Methods: An international multicenter survey of AIP was conducted in 15 institutes from 8 countries. We compared clinical and pathologic profiles of AIP (n = 731) and the clinical profiles of LPSP (n = 204) and IDCP (n = 64) patients. - Results: Patients with LPSP were approximately 16 years older than IDCP patients. Obstructive jaundice was a more frequent presentation in LPSP versus IDCP (75% vs 47%, P < 0.001), whereas abdominal pain (41% vs 68%, P < 0.001) and acute pancreatitis (5% vs 34%, P < 0.001) were more frequent in IDCP patients. Patients with LPSP were more likely to have diffuse swelling of the pancreas (40% vs 25%, P = 0.037) and elevated serum IgG4 levels (63% vs 23%, P < 0.001) but less likely to be associated with ulcerative colitis (1% vs 16%, P < 0.001). Clinical profiles of non-histologically confirmed AIP from Asia, the United States, and United Kingdom corresponded with that of LPSP, whereas those from Italy and Germany suggested a mixture of LPSP and IDCP. - Conclusions: Autoimmune pancreatitis is seen all around the world, with regional differences in the pathologic and clinical features. Lymphoplasmacytic sclerosing pancreatitis and IDCP have distinct clinical profiles.
Beschreibung:Gesehen am 07.07.2022
Beschreibung:Online Resource
ISSN:1536-4828
DOI:10.1097/MPA.0b013e3182258a15

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