Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial
Background Guidelines recommend endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as an initial investigatory technique for mediastinal nodal staging in lung cancer. However, EBUS-TBNA can be limited by the inadequacy of intact tissues, which might restrict its diagnostic...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
|
| In: |
The European respiratory journal
Year: 2021, Jahrgang: 58, Heft: 6, Pages: 1-9 |
| ISSN: | 1399-3003 |
| DOI: | 10.1183/13993003.00055-2021 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1183/13993003.00055-2021 Verlag, lizenzpflichtig, Volltext: https://erj.ersjournals.com/content/58/6/2100055 
|
| Verfasserangaben: | Jing Zhang, Jie-Ru Guo, Zan-Sheng Huang, Wan-Lei Fu, Xian-Li Wu, Na Wu, Wolfgang M. Kuebler, Felix J.F. Herth and Ye Fan |
| Zusammenfassung: | Background Guidelines recommend endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as an initial investigatory technique for mediastinal nodal staging in lung cancer. However, EBUS-TBNA can be limited by the inadequacy of intact tissues, which might restrict its diagnostic yield in mediastinal lesions of certain aetiologies. We have previously shown that EBUS-guided transbronchial mediastinal cryobiopsy can provide intact samples with greater volume. - Methods This randomised study determined the diagnostic yield and safety of transbronchial mediastinal cryobiopsy monitored by endosonography for the diagnosis of mediastinal lesions. Patients with a mediastinal lesion of ≥1 cm in the short axis were recruited. Following identification of the mediastinal lesion by linear EBUS, fine-needle aspiration and cryobiopsy were sequentially performed in a randomised order. Primary end-points were diagnostic yield, defined as the percentage of patients for whom mediastinal biopsy provided a definite diagnosis, and procedure-related adverse events. - Results In total, 197 patients were enrolled and randomly allocated. The overall diagnostic yield was 79.9% and 91.8% for TBNA and transbronchial mediastinal cryobiopsy, respectively (p=0.001). Diagnostic yields were similar for metastatic lymphadenopathy (94.1% versus 95.6%, p=0.58), while cryobiopsy was more sensitive than TBNA in uncommon tumours (91.7% versus 25.0%, p=0.001) and benign disorders (80.9% versus 53.2%, p=0.004). No significant differences in diagnostic yield were detected between “TBNA first” and “Cryobiopsy first” groups. We observed two cases of pneumothorax and one case of pneumomediastinum. - Conclusions Transbronchial cryobiopsy performed under EBUS guidance is a safe and useful approach that offers diagnostic histological samples of mediastinal lesions. - Tweetable abstract ERSpublications - click to tweetEBUS-guided transbronchial mediastinal cryobiopsy is a safe and promising novel diagnostic tool for mediastinal diseases that might allow for better histopathological evaluation and advanced testing https://bit.ly/3uiLkiD |
|---|---|
| Beschreibung: | Gesehen am 08.07.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1399-3003 |
| DOI: | 10.1183/13993003.00055-2021 |