Enhancers regulate progression of development in mammalian cells
During development and differentiation of an organism, accurate gene regulation is central for cells to maintain and balance their differentiation processes. Transcriptional interactions between cis -acting DNA elements such as promoters and enhancers are the basis for precise and balanced transcrip...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 July 2011
|
| In: |
Nucleic acids research
Year: 2011, Volume: 39, Issue: 20, Pages: 8689-8702 |
| ISSN: | 1362-4962 |
| DOI: | 10.1093/nar/gkr602 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/nar/gkr602
|
| Author Notes: | Anna-Lena Kranz, Roland Eils and Rainer König |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1809487005 | ||
| 003 | DE-627 | ||
| 005 | 20230428051957.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220708s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/nar/gkr602 |2 doi | |
| 035 | |a (DE-627)1809487005 | ||
| 035 | |a (DE-599)KXP1809487005 | ||
| 035 | |a (OCoLC)1341463593 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Kranz, Anna-Lena |e VerfasserIn |0 (DE-588)144022192 |0 (DE-627)656816368 |0 (DE-576)340384573 |4 aut | |
| 245 | 1 | 0 | |a Enhancers regulate progression of development in mammalian cells |c Anna-Lena Kranz, Roland Eils and Rainer König |
| 264 | 1 | |c 23 July 2011 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.07.2022 | ||
| 520 | |a During development and differentiation of an organism, accurate gene regulation is central for cells to maintain and balance their differentiation processes. Transcriptional interactions between cis -acting DNA elements such as promoters and enhancers are the basis for precise and balanced transcriptional regulation. We identified modules of combinations of binding sites in proximal and distal regulatory regions upstream of all transcription start sites (TSSs) in silico and applied these modules to gene expression time-series of mouse embryonic development and differentiation of human stem cells. In addition to tissue-specific regulation controlled by combinations of transcription factors (TFs) binding at promoters, we observed that in particular the combination of TFs binding at promoters together with TFs binding at the respective enhancers regulate highly specifically temporal progression during development: whereas 40% of TFs were specific for time intervals, 79% of TF pairs and even 97% of promoter-enhancer modules showed specificity for single time intervals of the human stem cells. Predominantly SP1 and E2F contributed to temporal specificity at promoters and the forkhead (FOX) family of TFs at enhancer regions. Altogether, we characterized three classes of TFs: with binding sites being enriched at the TSS (like SP1), depleted at the TSS (like FOX), and rather uniformly distributed. | ||
| 700 | 1 | |a Eils, Roland |d 1965- |e VerfasserIn |0 (DE-588)1020648287 |0 (DE-627)691291705 |0 (DE-576)361718195 |4 aut | |
| 700 | 1 | |a König, Rainer |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nucleic acids research |d Oxford : Oxford Univ. Press, 1974 |g 39(2011), 20, Seite 8689-8702 |h Online-Ressource |w (DE-627)26813250X |w (DE-600)1472175-2 |w (DE-576)07760878X |x 1362-4962 |7 nnas |a Enhancers regulate progression of development in mammalian cells |
| 773 | 1 | 8 | |g volume:39 |g year:2011 |g number:20 |g pages:8689-8702 |g extent:14 |a Enhancers regulate progression of development in mammalian cells |
| 856 | 4 | 0 | |u https://doi.org/10.1093/nar/gkr602 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220708 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1020648287 |a Eils, Roland |m 1020648287:Eils, Roland |d 160000 |d 160100 |e 160000PE1020648287 |e 160100PE1020648287 |k 0/160000/ |k 1/160000/160100/ |p 2 | ||
| 999 | |a KXP-PPN1809487005 |e 4162747865 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"physDesc":[{"extent":"14 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"display":"Kranz, Anna-Lena","family":"Kranz","role":"aut","given":"Anna-Lena"},{"family":"Eils","role":"aut","given":"Roland","display":"Eils, Roland"},{"family":"König","role":"aut","given":"Rainer","display":"König, Rainer"}],"title":[{"title":"Enhancers regulate progression of development in mammalian cells","title_sort":"Enhancers regulate progression of development in mammalian cells"}],"name":{"displayForm":["Anna-Lena Kranz, Roland Eils and Rainer König"]},"recId":"1809487005","id":{"eki":["1809487005"],"doi":["10.1093/nar/gkr602"]},"origin":[{"dateIssuedDisp":"23 July 2011","dateIssuedKey":"2011"}],"note":["Gesehen am 08.07.2022"],"relHost":[{"recId":"26813250X","disp":"Enhancers regulate progression of development in mammalian cellsNucleic acids research","origin":[{"publisherPlace":"Oxford","dateIssuedDisp":"1974-","publisher":"Oxford Univ. Press","dateIssuedKey":"1974"}],"id":{"zdb":["1472175-2"],"issn":["1362-4962"],"eki":["26813250X"]},"part":{"year":"2011","issue":"20","pages":"8689-8702","volume":"39","text":"39(2011), 20, Seite 8689-8702","extent":"14"},"titleAlt":[{"title":"NAR online"},{"title":"NAR"},{"title":"Database issue"},{"title":"Web server issue"}],"note":["Gesehen am 15.09.2025","Ungezählte Beil.: Database issue; Web server issue"],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"pubHistory":["1.1974 -"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Nucleic acids research","title_sort":"Nucleic acids research"}]}]} | ||
| SRT | |a KRANZANNALENHANCERSR2320 | ||