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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

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Oncogene-induced senescence has been shown to function as an intrinsic tumour suppressor mechanism. Lars Zender and colleagues now introduce the concept of 'senescence surveillance' by showing that premaligant senescent hepatocytes are cleared through a tumour antigen-directed immune respo...

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Main Authors: Kang, Tae-Won (Author) , Yevsa, Tetyana (Author) , Woller, Norman (Author) , Hoenicke, Lisa (Author) , Wuestefeld, Torsten (Author) , Dauch, Daniel (Author) , Hohmeyer, Anja (Author) , Gereke, Marcus (Author) , Rudalska, Ramona (Author) , Potapova, Anna (Author) , Iken, Marcus (Author) , Vucur, Mihael (Author) , Weiss, Siegfried (Author) , Heikenwalder, Mathias (Author) , Khan, Sadaf (Author) , Gil, Jesus (Author) , Bruder, Dunja (Author) , Manns, Michael (Author) , Schirmacher, Peter (Author) , Tacke, Frank (Author) , Ott, Michael (Author) , Luedde, Tom (Author) , Longerich, Thomas (Author) , Kubicka, Stefan (Author) , Zender, Lars (Author)
Format: Article (Journal)
Language:English
Published: 9 November 2011
In: Nature
Year: 2011, Volume: 479, Issue: 7374, Pages: 547-551
ISSN:1476-4687
DOI:10.1038/nature10599
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature10599
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature10599
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Author Notes:Tae-Won Kang, Tetyana Yevsa, Norman Woller, Lisa Hoenicke, Torsten Wuestefeld, Daniel Dauch, Anja Hohmeyer, Marcus Gereke, Ramona Rudalska, Anna Potapova, Marcus Iken, Mihael Vucur, Siegfried Weiss, Mathias Heikenwalder, Sadaf Khan, Jesus Gil, Dunja Bruder, Michael Manns, Peter Schirmacher, Frank Tacke, Michael Ott, Tom Luedde, Thomas Longerich, Stefan Kubickan & Lars Zender
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Summary:Oncogene-induced senescence has been shown to function as an intrinsic tumour suppressor mechanism. Lars Zender and colleagues now introduce the concept of 'senescence surveillance' by showing that premaligant senescent hepatocytes are cleared through a tumour antigen-directed immune response. This requires CD4+ T cells and suppresses the development of liver tumours in mouse models. The authors also provide evidence that senescent hepatocytes accumulate in the livers of immune-suppressed patients, demonstrating that senescence surveillance may also operate in humans. Strategies designed to harness antigen-specific immune surveillance of premalignant senescent cells may have potential in cancer prevention and therapy, and antigen-specific immune responses of this type may be relevant in vaccine production.
Item Description:Gesehen am 11.07.2022
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/nature10599

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