Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Oncogene-induced senescence has been shown to function as an intrinsic tumour suppressor mechanism. Lars Zender and colleagues now introduce the concept of 'senescence surveillance' by showing that premaligant senescent hepatocytes are cleared through a tumour antigen-directed immune respo...

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Main Authors:	Kang, Tae-Won (Author) , Yevsa, Tetyana (Author) , Woller, Norman (Author) , Hoenicke, Lisa (Author) , Wuestefeld, Torsten (Author) , Dauch, Daniel (Author) , Hohmeyer, Anja (Author) , Gereke, Marcus (Author) , Rudalska, Ramona (Author) , Potapova, Anna (Author) , Iken, Marcus (Author) , Vucur, Mihael (Author) , Weiss, Siegfried (Author) , Heikenwalder, Mathias (Author) , Khan, Sadaf (Author) , Gil, Jesus (Author) , Bruder, Dunja (Author) , Manns, Michael (Author) , Schirmacher, Peter (Author) , Tacke, Frank (Author) , Ott, Michael (Author) , Luedde, Tom (Author) , Longerich, Thomas (Author) , Kubicka, Stefan (Author) , Zender, Lars (Author)
Format:	Article (Journal)
Language:	English
Published:	9 November 2011
In:	Nature Year: 2011, Volume: 479, Issue: 7374, Pages: 547-551
ISSN:	1476-4687
DOI:	10.1038/nature10599
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature10599 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature10599
Author Notes:	Tae-Won Kang, Tetyana Yevsa, Norman Woller, Lisa Hoenicke, Torsten Wuestefeld, Daniel Dauch, Anja Hohmeyer, Marcus Gereke, Ramona Rudalska, Anna Potapova, Marcus Iken, Mihael Vucur, Siegfried Weiss, Mathias Heikenwalder, Sadaf Khan, Jesus Gil, Dunja Bruder, Michael Manns, Peter Schirmacher, Frank Tacke, Michael Ott, Tom Luedde, Thomas Longerich, Stefan Kubickan & Lars Zender