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A measurement setup for direct 17O MRI at 7 T

An efficient breathing system was designed for direct 17O MRI to perform oxygen metabolism studies of the human brain. The breathing system consists of a demand oxygen delivery device for 17O2 supply and a custom-built re-breathing circuit with pneumatic switching valve. To efficiently deliver the 1...

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Hauptverfasser: Hoffmann, Stefan Heinrich (VerfasserIn) , Begovatz, Paul (VerfasserIn) , Nagel, Armin Michael (VerfasserIn) , Umathum, Reiner (VerfasserIn) , Schommer, Kai (VerfasserIn) , Bachert, Peter (VerfasserIn) , Bock, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [October 2011]
In: Magnetic resonance in medicine
Year: 2011, Jahrgang: 66, Heft: 4, Pages: 1109-1115
ISSN:1522-2594
DOI:10.1002/mrm.22871
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/mrm.22871
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.22871
Volltext
Verfasserangaben:Stefan H. Hoffmann, Paul Begovatz, Armin M. Nagel, Reiner Umathum, Kai Schommer, Peter Bachert, and Michael Bock

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520 |a An efficient breathing system was designed for direct 17O MRI to perform oxygen metabolism studies of the human brain. The breathing system consists of a demand oxygen delivery device for 17O2 supply and a custom-built re-breathing circuit with pneumatic switching valve. To efficiently deliver the 17O gas to the alveoli of the lungs, the system applies short gas pulses upon an inspiration trigger via a nasal cannula. During and after 17O2 administration, the exhaled gas volumes are stored and filtered in the re-breathing section to make the most efficient use of the rare 17O gas. In an inhalation experiment, 2.2 ± 0.1 L of 70%-enriched 17O2 were administered to a healthy volunteer and direct 17O MRI was performed for a total imaging time of 38 min with a temporal resolution of 50 s per 3D data set. Mapping of the maximum signal increase was carried out showing regional variations of oxygen concentration of up to 30% over the natural abundance of 17O water. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. 
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