Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)
Cryopyrin-associated periodic syndrome (CAPS) represents a spectrum of three auto-inflammatory syndromes, familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease/chronic infantile neurological cutaneous and articular syndrome...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 February 2011
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| In: |
Arthritis Research & Therapy
Year: 2011, Jahrgang: 13, Pages: 1-10 |
| ISSN: | 1465-9913 |
| DOI: | 10.1186/ar3266 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/ar3266
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| Verfasserangaben: | Jasmin B. Kuemmerle-Deschner, Eduardo Ramos, Norbert Blank, Joachim Roesler, Sandra D. Felix, Thomas Jung, Kirstin Stricker, Abhijit Chakraborty, Stacey Tannenbaum, Andrew M. Wright and Christiane Rordorf |
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| 245 | 1 | 0 | |a Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS) |c Jasmin B. Kuemmerle-Deschner, Eduardo Ramos, Norbert Blank, Joachim Roesler, Sandra D. Felix, Thomas Jung, Kirstin Stricker, Abhijit Chakraborty, Stacey Tannenbaum, Andrew M. Wright and Christiane Rordorf |
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| 520 | |a Cryopyrin-associated periodic syndrome (CAPS) represents a spectrum of three auto-inflammatory syndromes, familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease/chronic infantile neurological cutaneous and articular syndrome (NOMID/CINCA) with etiology linked to mutations in the NLRP3 gene resulting in elevated interleukin-1β (IL-1β) release. CAPS is a rare hereditary auto-inflammatory disease, which may start early in childhood and requires a life-long treatment. Canakinumab, a fully human anti-IL-1β antibody, produces sustained selective inhibition of IL-1β. This study was conducted to assess the efficacy, safety, and pharmacokinetics of canakinumab in the treatment of pediatric CAPS patients. | ||
| 650 | 4 | |a Anakinra | |
| 650 | 4 | |a Canakinumab | |
| 650 | 4 | |a Minimal Disease Activity | |
| 650 | 4 | |a NLRP3 Gene | |
| 650 | 4 | |a V198M Mutation | |
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| 700 | 1 | |a Roesler, Joachim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Felix, Sandra D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jung, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stricker, Kirstin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chakraborty, Abhijit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tannenbaum, Stacey |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wright, Andrew M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rordorf, Christiane |e VerfasserIn |4 aut | |
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