Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas: a prospective single-arm monocentric phase-II study (RNOP-05)
The objective of this prospective, monocentric phase-II pilot study was to evaluate toxicity and efficacy of neoadjuvant temozolomide (TMZ) and 13-cis retinoic acid (13-cRA) treatment in patients with newly diagnosed anaplastic gliomas after total or subtotal tumor resection. The primary endpoint of...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 March 2011
|
| In: |
Journal of neuro-oncology
Year: 2011, Jahrgang: 104, Heft: 3, Pages: 801-809 |
| ISSN: | 1573-7373 |
| DOI: | 10.1007/s11060-011-0548-y |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s11060-011-0548-y Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s11060-011-0548-y 
|
| Verfasserangaben: | Oliver Grauer, Christina Pascher, Christian Hartmann, Florian Zeman, Michael Weller, Martin Proescholdt, Alexander Brawanski, Thorsten Pietsch, Wolfgang Wick, Ulrich Bogdahn, Peter Hau |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1809699614 | ||
| 003 | DE-627 | ||
| 005 | 20240416193743.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220711s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11060-011-0548-y |2 doi | |
| 035 | |a (DE-627)1809699614 | ||
| 035 | |a (DE-599)KXP1809699614 | ||
| 035 | |a (OCoLC)1341463875 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Grauer, Oliver Martin |d 1969- |e VerfasserIn |0 (DE-588)140865675 |0 (DE-627)623101211 |0 (DE-576)321117115 |4 aut | |
| 245 | 1 | 0 | |a Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas |b a prospective single-arm monocentric phase-II study (RNOP-05) |c Oliver Grauer, Christina Pascher, Christian Hartmann, Florian Zeman, Michael Weller, Martin Proescholdt, Alexander Brawanski, Thorsten Pietsch, Wolfgang Wick, Ulrich Bogdahn, Peter Hau |
| 264 | 1 | |c 4 March 2011 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.07.2022 | ||
| 520 | |a The objective of this prospective, monocentric phase-II pilot study was to evaluate toxicity and efficacy of neoadjuvant temozolomide (TMZ) and 13-cis retinoic acid (13-cRA) treatment in patients with newly diagnosed anaplastic gliomas after total or subtotal tumor resection. The primary endpoint of the study was median progression-free survival (PFS). Secondary endpoints were toxicity and PFS rates at 6, 12 and 24 months. Thirty-two adult patients were included in the study and treated with a median number of 10 TMZ and 13-cRA cycles (range 1-26). The majority of patients had favorable prognostic factors characterized by young age, complete resection, oligodendroglial histology, 1p/19q co-deletion, O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation and isocitrate dehydrogenase 1 (IDH1) mutation. Grade 3/4 myelotoxicity occurred in 5/32 patients, and about 90% of patients suffered from grade 2/3 adverse events attributable to 13-cRA. The median PFS was 37.8 months (95% CI 22.2-53.4). The 6-, 12- and 24-month PFS rates were 84.4, 75 and 42.4%. The extent of tumor resection was the only prognostic factor associated with better PFS. TMZ and 13-cRA treatment did not improve PFS when retrospectively compared to the TMZ-treated group within the randomized NOA-04 phase-III trial. In conclusion, 13-cRA addition to TMZ in a neoadjuvant setting showed acceptable toxicity, but did not yield an advantage in PFS in patients with newly diagnosed anaplastic gliomas after total or subtotal tumor resection. | ||
| 650 | 4 | |a 13-cis retinoic acid | |
| 650 | 4 | |a 1p/19q co-deletion | |
| 650 | 4 | |a Anaplastic glioma | |
| 650 | 4 | |a IDH1 | |
| 650 | 4 | |a MGMT | |
| 650 | 4 | |a Temozolomide | |
| 700 | 1 | |a Pascher, Christina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hartmann, Christian |e VerfasserIn |0 (DE-588)1030180539 |0 (DE-627)734895240 |0 (DE-576)377991465 |4 aut | |
| 700 | 1 | |a Zeman, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weller, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Proescholdt, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brawanski, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pietsch, Thorsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 700 | 1 | |a Bogdahn, Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hau, Peter |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuro-oncology |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 |g 104(2011), 3, Seite 801-809 |h Online-Ressource |w (DE-627)32046122X |w (DE-600)2007293-4 |w (DE-576)107058944 |x 1573-7373 |7 nnas |a Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas a prospective single-arm monocentric phase-II study (RNOP-05) |
| 773 | 1 | 8 | |g volume:104 |g year:2011 |g number:3 |g pages:801-809 |g extent:9 |a Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas a prospective single-arm monocentric phase-II study (RNOP-05) |
| 787 | 0 | 8 | |i Errata |a Grauer, Oliver Martin, 1969 - |t Erratum to |d 2011 |w (DE-627)1809700752 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s11060-011-0548-y |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s11060-011-0548-y |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220711 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 9 | ||
| 998 | |g 1030180539 |a Hartmann, Christian |m 1030180539:Hartmann, Christian |d 50000 |e 50000PH1030180539 |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1809699614 |e 4163850198 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Oliver Grauer, Christina Pascher, Christian Hartmann, Florian Zeman, Michael Weller, Martin Proescholdt, Alexander Brawanski, Thorsten Pietsch, Wolfgang Wick, Ulrich Bogdahn, Peter Hau"]},"id":{"eki":["1809699614"],"doi":["10.1007/s11060-011-0548-y"]},"recId":"1809699614","physDesc":[{"extent":"9 S."}],"origin":[{"dateIssuedDisp":"4 March 2011","dateIssuedKey":"2011"}],"person":[{"role":"aut","given":"Oliver Martin","family":"Grauer","display":"Grauer, Oliver Martin"},{"family":"Pascher","role":"aut","given":"Christina","display":"Pascher, Christina"},{"family":"Hartmann","given":"Christian","role":"aut","display":"Hartmann, Christian"},{"display":"Zeman, Florian","family":"Zeman","role":"aut","given":"Florian"},{"family":"Weller","given":"Michael","role":"aut","display":"Weller, Michael"},{"family":"Proescholdt","given":"Martin","role":"aut","display":"Proescholdt, Martin"},{"family":"Brawanski","role":"aut","given":"Alexander","display":"Brawanski, Alexander"},{"display":"Pietsch, Thorsten","family":"Pietsch","given":"Thorsten","role":"aut"},{"display":"Wick, Wolfgang","given":"Wolfgang","role":"aut","family":"Wick"},{"family":"Bogdahn","role":"aut","given":"Ulrich","display":"Bogdahn, Ulrich"},{"display":"Hau, Peter","family":"Hau","role":"aut","given":"Peter"}],"relHost":[{"note":["Gesehen am 11.06.2018","Fortsetzung der Druck-Ausgabe"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"pages":"801-809","issue":"3","extent":"9","text":"104(2011), 3, Seite 801-809","year":"2011","volume":"104"},"title":[{"title_sort":"Journal of neuro-oncology","title":"Journal of neuro-oncology"}],"id":{"zdb":["2007293-4"],"eki":["32046122X"],"issn":["1573-7373"]},"pubHistory":["1.1983 -"],"origin":[{"publisher":"Springer Science + Business Media B.V ; Kluwer","dateIssuedKey":"1983","publisherPlace":"Dordrecht [u.a.] ; Dordrecht [u.a.]","dateIssuedDisp":"1983-"}],"disp":"Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas a prospective single-arm monocentric phase-II study (RNOP-05)Journal of neuro-oncology","physDesc":[{"extent":"Online-Ressource"}],"recId":"32046122X"}],"title":[{"subtitle":"a prospective single-arm monocentric phase-II study (RNOP-05)","title":"Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas","title_sort":"Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 11.07.2022"]} | ||
| SRT | |a GRAUEROLIVTEMOZOLOMI4201 | ||