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Temporal profile of release of interleukin-1β in neurotrauma

Timing and extent of trauma-induced release of interleukin-1beta (IL-1beta) in extracellular fluid of the CNS were analyzed. In brain tissue perfusates obtained by in vivo microdialysis a marked release of IL-1beta was unexpectedly detected within less than 60 min. At such an early stage of neurotra...

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Main Authors: Faßbender, Klaus (Author) , Schneider, Susanne (Author) , Bertsch, Thomas (Author) , Schlüter, Dirk (Author) , Fatar, Marc (Author) , Ragoschke-Schumm, Andreas (Author) , Kühl, Sandra (Author) , Kischka, Udo (Author) , Hennerici, Michael G. (Author)
Format: Article (Journal)
Language:English
Published: 18 April 2000
In: Neuroscience letters
Year: 2000, Volume: 284, Issue: 3, Pages: 135-138
ISSN:1872-7972
DOI:10.1016/s0304-3940(00)00977-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/s0304-3940(00)00977-0
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Author Notes:Klaus Fassbender, Susanne Schneider, Thomas Bertsch, Dirk Schlueter, Marc Fatar, Andreas Ragoschke, Sandra Kühl, Udo Kischka, Michael Hennerici

MARC

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520 |a Timing and extent of trauma-induced release of interleukin-1beta (IL-1beta) in extracellular fluid of the CNS were analyzed. In brain tissue perfusates obtained by in vivo microdialysis a marked release of IL-1beta was unexpectedly detected within less than 60 min. At such an early stage of neurotrauma, mRNA expression of IL-1beta was detected whereas immunoreactivity for the IL-1beta protein was negative. Concentrations of extracellularly secreted IL-1beta protein gradually increased, peaked at day 2 and decreased thereafter. Drugs acting on mononuclear phagocytes significantly modulated IL-1beta secretion. This so far unrecognized acuity of IL-1beta release demonstrated here, may represent a precondition for the orchestrating role of this mediator in the cascade of inflammatory host response. 
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