Gram-positive Staphylococcus aureus LTA promotes distinct memory-like effects in murine bone marrow neutrophils
Neutrophils primarily act as first responders in acute infection and directly maintain inflammatory responses. However, a growing body of evidence suggests that neutrophils also bear the potential to mediate chronic inflammation by exhibiting memory-like features. We now asked whether bone marrow-de...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
7 May 2022
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| In: |
Cellular immunology
Year: 2022, Volume: 376, Pages: 1-9 |
| ISSN: | 1090-2163 |
| DOI: | 10.1016/j.cellimm.2022.104535 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cellimm.2022.104535 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0008874922000594 
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| Author Notes: | Trim Lajqi, David Frommhold, Maylis Braun, Simon Alexander Kranig, Johannes Pöschl, Hannes Hudalla |
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| 520 | |a Neutrophils primarily act as first responders in acute infection and directly maintain inflammatory responses. However, a growing body of evidence suggests that neutrophils also bear the potential to mediate chronic inflammation by exhibiting memory-like features. We now asked whether bone marrow-derived murine neutrophils can be primed by lipoteichoic acid (LTA) from gram-positive S. aureus. We found that low-dose (1ng/mL) LTA-priming promoted increased production of pro-inflammatory mediators (TNF-α, IL-6, ROS), whereas high-dose (10µg/mL) priming resulted in opposing reactions marked by increased IL-10 and suppressed pro-inflammatory mediators upon a second stimulus. A similar pattern of pro-inflammatory activation (trained sensitivity) and anti-inflammatory properties (tolerance) was recapitulated in cellular functional in vitro assays (transmigration and phagocytosis). Priming by LTA correlated with TLR2/MyD88-mediated regulation of NFκB-p65 through intermediate PI3Ks/MAPK. Collectively, our data suggest a previously unknown capacity of neutrophils to be differentially primed by varying doses of LTA, endorsing memory-like features in neutrophils. | ||
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