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Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

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Single nucleotide variants (SNVs) are prevalent genetic factors shaping individual trait profiles and disease susceptibility. The recent development and optimizations of base editors, rubber and pencil genome editing tools now promise to enable direct functional assessment of SNVs in model organisms...

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Main Authors: Cornean, Alex (Author) , Gierten, Jakob (Author) , Welz, Bettina (Author) , Mateo, Juan L. (Author) , Thumberger, Thomas (Author) , Wittbrodt, Joachim (Author)
Format: Article (Journal)
Language:English
Published: 04 April 2022
In: eLife
Year: 2022, Volume: 11, Pages: 1-34
ISSN:2050-084X
DOI:10.7554/eLife.72124
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.72124
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Author Notes:Alex Cornean, Jakob Gierten, Bettina Welz, Juan Luis Mateo, Thomas Thumberger, Joachim Wittbrodt
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Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction by Cornean, Alex (Author) , Gierten, Jakob (Author) , Welz, Bettina (Author) , Mateo, Juan L. (Author) , Thumberger, Thomas (Author) , Wittbrodt, Joachim (Author) ,


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