Cover Image

Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults

Background and purpose - Proton beam radiotherapy (PRT) is used in the treatment of low-grade glioma (LGG) to mitigate long-term sequelae. Following PRT, increased rates of radiation-induced contrast enhancements (RICE) are suspected but poorly understood. - Materials and methods - We analyzed conse...

Full description

Saved in:
Bibliographic Details
Main Authors: Eichkorn, Tanja (Author) , Bauer, Julia (Author) , Bahn, Emanuel (Author) , Lischalk, Jonathan W. (Author) , Meixner, Eva (Author) , Sandrini, Elisabetta (Author) , Regnery, Sebastian (Author) , Held, Thomas (Author) , Hörner-Rieber, Juliane (Author) , Alber, Markus (Author) , Herfarth, Klaus (Author) , Debus, Jürgen (Author) , König, Laila (Author) , Harrabi, Semi B. (Author)
Format: Article (Journal)
Language:English
Published: 20 May 2022
In: Radiotherapy and oncology
Year: 2022, Volume: 172, Pages: 54-64
ISSN:1879-0887
DOI:10.1016/j.radonc.2022.05.005
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2022.05.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814022002419
Get full text
Author Notes:Tanja Eichkorn, Julia Bauer, Emanuel Bahn, Jonathan W. Lischalk, Eva Meixner, Elisabetta Sandrini, Sebastian Regnery, Thomas Held, Juliane Hörner-Rieber, Markus Alber, Klaus Herfarth, Jürgen Debus, Laila König, Semi Harrabi

MARC

LEADER 00000caa a2200000 c 4500
001 1810702623
003 DE-627
005 20240416193756.0
007 cr uuu---uuuuu
008 220718s2022 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.radonc.2022.05.005  |2 doi 
035 |a (DE-627)1810702623 
035 |a (DE-599)KXP1810702623 
035 |a (OCoLC)1341464158 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Eichkorn, Tanja  |e VerfasserIn  |0 (DE-588)1191801187  |0 (DE-627)167027666X  |4 aut 
245 1 0 |a Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults  |c Tanja Eichkorn, Julia Bauer, Emanuel Bahn, Jonathan W. Lischalk, Eva Meixner, Elisabetta Sandrini, Sebastian Regnery, Thomas Held, Juliane Hörner-Rieber, Markus Alber, Klaus Herfarth, Jürgen Debus, Laila König, Semi Harrabi 
264 1 |c 20 May 2022 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 18.07.2022 
520 |a Background and purpose - Proton beam radiotherapy (PRT) is used in the treatment of low-grade glioma (LGG) to mitigate long-term sequelae. Following PRT, increased rates of radiation-induced contrast enhancements (RICE) are suspected but poorly understood. - Materials and methods - We analyzed consecutive 227 patients (42 children and 185 adults) treated with PRT (54 Gy RBE) for LGG from 2010 to 2020 and followed with serial clinical exams and magnetic resonance imaging for in median 5.6 years. - Results - Tumors were graded WHO 1 in a minority (n = 22, 12%) of adults, but a majority of children (n = 29, 69%). In contrast, tumors were graded WHO 2 in the majority (n = 160, 87%) of adults and a minority of children (n = 10, 24%). Five-year overall survival following PRT was 81% in adults and 91% in children. The risk of RICE was 5-fold more frequent in adults (25%) vs. children (5%; p = 0.0043). In children and adults, RICE were symptomatic in 50% and 55% (n = 1 and 26) of cases with CTCAE grade 0 in 47% (n = 23), grade 1 in 25% (n = 12), 0% grade 2 (n = 0) and 29% grade 3 (n = 14), respectively. In adults, RICE risk was associated to WHO grading (8% in WHO grade 1 vs. 24% in WHO grade 2, p = 0.026), independent of age (p = 0.44) and irradiation dose (p = 0.005), but not independent of IDH mutational status. - Conclusions - These data demonstrate effectiveness of PRT for LGG in both children and adults. The RICE risk is lower in children which are a main target group for PRT and differs with WHO grading. 
650 4 |a Low-grade glioma (LGG) 
650 4 |a Pediatric brain tumors 
650 4 |a Proton radiotherapy 
650 4 |a Pseudoprogression/Radiation necrosis 
650 4 |a Radiation-induced contrast enhancements (RICE) 
700 1 |a Bauer, Julia  |e VerfasserIn  |0 (DE-588)107489099X  |0 (DE-627)832650145  |0 (DE-576)443090904  |4 aut 
700 1 |a Bahn, Emanuel  |e VerfasserIn  |0 (DE-588)1199956562  |0 (DE-627)1682098605  |4 aut 
700 1 |a Lischalk, Jonathan W.  |e VerfasserIn  |4 aut 
700 1 |a Meixner, Eva  |e VerfasserIn  |0 (DE-588)1222706334  |0 (DE-627)174193141X  |4 aut 
700 1 |a Sandrini, Elisabetta  |e VerfasserIn  |0 (DE-588)1256722669  |0 (DE-627)1800758421  |4 aut 
700 1 |a Regnery, Sebastian  |e VerfasserIn  |0 (DE-588)1182554776  |0 (DE-627)1662804199  |4 aut 
700 1 |a Held, Thomas  |d 1990-  |e VerfasserIn  |0 (DE-588)1172053723  |0 (DE-627)104086970X  |0 (DE-576)513977627  |4 aut 
700 1 |a Hörner-Rieber, Juliane  |d 1985-  |e VerfasserIn  |0 (DE-588)1025307631  |0 (DE-627)722020511  |0 (DE-576)370188039  |4 aut 
700 1 |a Alber, Markus  |e VerfasserIn  |0 (DE-588)1145057101  |0 (DE-627)1005461767  |0 (DE-576)495602507  |4 aut 
700 1 |a Herfarth, Klaus  |e VerfasserIn  |0 (DE-588)1032757582  |0 (DE-627)739273116  |0 (DE-576)171352289  |4 aut 
700 1 |a Debus, Jürgen  |d 1964-  |e VerfasserIn  |0 (DE-588)1022671421  |0 (DE-627)717025780  |0 (DE-576)365774944  |4 aut 
700 1 |a König, Laila  |d 1986-  |e VerfasserIn  |0 (DE-588)1053640579  |0 (DE-627)790403315  |0 (DE-576)409584282  |4 aut 
700 1 |a Harrabi, Semi B.  |d 1986-  |e VerfasserIn  |0 (DE-588)1044730161  |0 (DE-627)772596034  |0 (DE-576)398081298  |4 aut 
773 0 8 |i Enthalten in  |t Radiotherapy and oncology  |d Amsterdam [u.a.] : Elsevier Science, 1983  |g 172(2022), Seite 54-64  |h Online-Ressource  |w (DE-627)306710110  |w (DE-600)1500707-8  |w (DE-576)082435731  |x 1879-0887  |7 nnas  |a Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults 
773 1 8 |g volume:172  |g year:2022  |g pages:54-64  |g extent:11  |a Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults 
856 4 0 |u https://doi.org/10.1016/j.radonc.2022.05.005  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0167814022002419  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20220718 
993 |a Article 
994 |a 2022 
998 |g 1044730161  |a Harrabi, Semi B.  |m 1044730161:Harrabi, Semi B.  |d 910000  |d 911400  |e 910000PH1044730161  |e 911400PH1044730161  |k 0/910000/  |k 1/910000/911400/  |p 14  |y j 
998 |g 1053640579  |a König, Laila  |m 1053640579:König, Laila  |d 910000  |d 911400  |e 910000PK1053640579  |e 911400PK1053640579  |k 0/910000/  |k 1/910000/911400/  |p 13 
998 |g 1022671421  |a Debus, Jürgen  |m 1022671421:Debus, Jürgen  |d 910000  |d 911400  |e 910000PD1022671421  |e 911400PD1022671421  |k 0/910000/  |k 1/910000/911400/  |p 12 
998 |g 1032757582  |a Herfarth, Klaus  |m 1032757582:Herfarth, Klaus  |d 910000  |d 911400  |d 50000  |e 910000PH1032757582  |e 911400PH1032757582  |e 50000PH1032757582  |k 0/910000/  |k 1/910000/911400/  |k 0/50000/  |p 11 
998 |g 1145057101  |a Alber, Markus  |m 1145057101:Alber, Markus  |d 910000  |d 911400  |e 910000PA1145057101  |e 911400PA1145057101  |k 0/910000/  |k 1/910000/911400/  |p 10 
998 |g 1025307631  |a Hörner-Rieber, Juliane  |m 1025307631:Hörner-Rieber, Juliane  |d 910000  |d 911400  |e 910000PH1025307631  |e 911400PH1025307631  |k 0/910000/  |k 1/910000/911400/  |p 9 
998 |g 1172053723  |a Held, Thomas  |m 1172053723:Held, Thomas  |d 910000  |d 911400  |e 910000PH1172053723  |e 911400PH1172053723  |k 0/910000/  |k 1/910000/911400/  |p 8 
998 |g 1182554776  |a Regnery, Sebastian  |m 1182554776:Regnery, Sebastian  |d 910000  |d 911400  |e 910000PR1182554776  |e 911400PR1182554776  |k 0/910000/  |k 1/910000/911400/  |p 7 
998 |g 1256722669  |a Sandrini, Elisabetta  |m 1256722669:Sandrini, Elisabetta  |d 910000  |d 911400  |e 910000PS1256722669  |e 911400PS1256722669  |k 0/910000/  |k 1/910000/911400/  |p 6 
998 |g 1222706334  |a Meixner, Eva  |m 1222706334:Meixner, Eva  |d 910000  |d 911400  |e 910000PM1222706334  |e 911400PM1222706334  |k 0/910000/  |k 1/910000/911400/  |p 5 
998 |g 1199956562  |a Bahn, Emanuel  |m 1199956562:Bahn, Emanuel  |d 910000  |d 911400  |e 910000PB1199956562  |e 911400PB1199956562  |k 0/910000/  |k 1/910000/911400/  |p 3 
998 |g 107489099X  |a Bauer, Julia  |m 107489099X:Bauer, Julia  |d 910000  |d 911400  |e 910000PB107489099X  |e 911400PB107489099X  |k 0/910000/  |k 1/910000/911400/  |p 2 
998 |g 1191801187  |a Eichkorn, Tanja  |m 1191801187:Eichkorn, Tanja  |d 910000  |d 911400  |e 910000PE1191801187  |e 911400PE1191801187  |k 0/910000/  |k 1/910000/911400/  |p 1  |x j 
999 |a KXP-PPN1810702623  |e 4169416422 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"11 S."}],"recId":"1810702623","origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"20 May 2022"}],"relHost":[{"recId":"306710110","physDesc":[{"extent":"Online-Ressource"}],"disp":"Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adultsRadiotherapy and oncology","origin":[{"publisher":"Elsevier Science","dateIssuedDisp":"1983-","dateIssuedKey":"1983","publisherPlace":"Amsterdam [u.a.]"}],"title":[{"title_sort":"Radiotherapy and oncology","title":"Radiotherapy and oncology","subtitle":"journal of the European Society for Therapeutic Radiology and Oncology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 30.05.15","Ungezählte Beil.: Supplement"],"pubHistory":["1.1983 -"],"titleAlt":[{"title":"The green journal"}],"id":{"eki":["306710110"],"issn":["1879-0887"],"zdb":["1500707-8"]},"part":{"extent":"11","volume":"172","text":"172(2022), Seite 54-64","year":"2022","pages":"54-64"}}],"person":[{"display":"Eichkorn, Tanja","family":"Eichkorn","given":"Tanja","role":"aut"},{"given":"Julia","role":"aut","family":"Bauer","display":"Bauer, Julia"},{"given":"Emanuel","role":"aut","family":"Bahn","display":"Bahn, Emanuel"},{"role":"aut","given":"Jonathan W.","family":"Lischalk","display":"Lischalk, Jonathan W."},{"given":"Eva","role":"aut","family":"Meixner","display":"Meixner, Eva"},{"role":"aut","given":"Elisabetta","family":"Sandrini","display":"Sandrini, Elisabetta"},{"display":"Regnery, Sebastian","family":"Regnery","given":"Sebastian","role":"aut"},{"family":"Held","role":"aut","given":"Thomas","display":"Held, Thomas"},{"given":"Juliane","role":"aut","family":"Hörner-Rieber","display":"Hörner-Rieber, Juliane"},{"given":"Markus","role":"aut","family":"Alber","display":"Alber, Markus"},{"given":"Klaus","role":"aut","family":"Herfarth","display":"Herfarth, Klaus"},{"family":"Debus","role":"aut","given":"Jürgen","display":"Debus, Jürgen"},{"family":"König","role":"aut","given":"Laila","display":"König, Laila"},{"role":"aut","given":"Semi B.","family":"Harrabi","display":"Harrabi, Semi B."}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 18.07.2022"],"title":[{"title":"Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults","title_sort":"Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults"}],"name":{"displayForm":["Tanja Eichkorn, Julia Bauer, Emanuel Bahn, Jonathan W. Lischalk, Eva Meixner, Elisabetta Sandrini, Sebastian Regnery, Thomas Held, Juliane Hörner-Rieber, Markus Alber, Klaus Herfarth, Jürgen Debus, Laila König, Semi Harrabi"]},"id":{"eki":["1810702623"],"doi":["10.1016/j.radonc.2022.05.005"]}} 
SRT |a EICHKORNTARADIATIONI2020 

Similar Items