Acceleration of thrombolysis with ultrasound through the cranium in a flow model
Thrombolysis is an efficient therapy for hyperacute stroke within a limited time window. Neurological outcome depends on the recanalization time of the occluded vessel. Nonthermal effects of low-frequency ultrasound (US) accelerate enzymatic fibrinolysis in vitro. We examined the effects of transcra...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 August 2000
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| In: |
Ultrasound in medicine & biology
Year: 2000, Jahrgang: 26, Heft: 5, Pages: 889-895 |
| ISSN: | 1879-291X |
| DOI: | 10.1016/s0301-5629(00)00211-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/s0301-5629(00)00211-8
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| Verfasserangaben: | Konstantinos Spengos, Stephan Behrens, Michael Daffertshofer, Carl E. Dempfle and Michael Hennerici |
MARC
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| 245 | 1 | 0 | |a Acceleration of thrombolysis with ultrasound through the cranium in a flow model |c Konstantinos Spengos, Stephan Behrens, Michael Daffertshofer, Carl E. Dempfle and Michael Hennerici |
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| 520 | |a Thrombolysis is an efficient therapy for hyperacute stroke within a limited time window. Neurological outcome depends on the recanalization time of the occluded vessel. Nonthermal effects of low-frequency ultrasound (US) accelerate enzymatic fibrinolysis in vitro. We examined the effects of transcranially applied US on recombinant tissue plasminogen activator (rt-PA)-mediated thrombolysis in a flow model in vitro. Pure fibrin clots were placed in a continuous-pressure flow model and treated with rt-PA during 1-MHz US exposure (0.5 W/cm(2); spatial peak, temporal peak intensity). Transcranial and direct US application in combination with rt-PA significantly (p<0.001) shortened recanalization time, increased perfusion flow and reperfusion rate in comparison with rt-PA-mediated thrombolysis alone. Recanalization rate within 30 min was 90-100% in the US-exposed clots vs. 30% in the clots treated only with rt-PA. Our results suggest that transcranial application of 1-MHz US may accelerate reperfusion and recanalization rate of occluded intracerebral vessels by enhancing rt-PA-mediated thrombolysis. Shortening of recanalization time could contribute to optimizing effects of acute thrombolytic stroke therapy. | ||
| 650 | 4 | |a Blood Flow Velocity | |
| 650 | 4 | |a Brain Ischemia | |
| 650 | 4 | |a Cerebrovascular Circulation | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a In Vitro Techniques | |
| 650 | 4 | |a Models, Biological | |
| 650 | 4 | |a Phantoms, Imaging | |
| 650 | 4 | |a Plasminogen Activators | |
| 650 | 4 | |a Recombinant Proteins | |
| 650 | 4 | |a Thrombolytic Therapy | |
| 650 | 4 | |a Tissue Plasminogen Activator | |
| 650 | 4 | |a Ultrasonography, Doppler, Transcranial | |
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