Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome
Wolfram syndrome is a rare genetic disorder characterized by endocrine dysfunction and progressive neurodegeneration. By targeting intracellular calcium dysregulations, a sigma-1 receptor agonist rescued neurological deficits in preclinical models of Wolfram syndrome.
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 March 2022
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| In: |
Cell calcium
Year: 2022, Volume: 104, Pages: 1-3 |
| ISSN: | 1532-1991 |
| DOI: | 10.1016/j.ceca.2022.102572 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ceca.2022.102572 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0143416022000471 
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| Author Notes: | Tom T. Fischer, Lien D. Nguyen, Barbara E. Ehrlich |
MARC
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