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Sex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease: results from COSYCONET

In patients with COPD, it has not been comprehensively assessed whether the predictive value of comorbidities for mortality differs between men and women. We therefore aimed to examine sex differences of COPD comorbidities in regard with prognosis by classifying comorbidities into a comorbidome rela...

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Main Authors: Trudzinski, Franziska (Author) , Jörres, Rudolf A. (Author) , Alter, Peter (Author) , Walter, Julia (Author) , Watz, Henrik (Author) , Koch, Andrea (Author) , John, Matthias (Author) , Lommatzsch, Marek (Author) , Vogelmeier, Claus F. (Author) , Kauczor, Hans-Ulrich (Author) , Welte, Tobias (Author) , Behr, Jürgen (Author) , Tufman, Amanda (Author) , Bals, Robert (Author) , Herth, Felix (Author) , Kahnert, Kathrin (Author)
Format: Article (Journal)
Language:English
Published: 24 May 2022
In: Scientific reports
Year: 2022, Volume: 12, Pages: 1-10
ISSN:2045-2322
DOI:10.1038/s41598-022-12828-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-022-12828-8
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-022-12828-8
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Author Notes:Franziska C. Trudzinski, Rudolf A. Jörres, Peter Alter, Julia Walter, Henrik Watz, Andrea Koch, Matthias John, Marek Lommatzsch, Claus F. Vogelmeier, Hans-Ulrich Kauczor, Tobias Welte, Jürgen Behr, Amanda Tufman, Robert Bals, Felix J.F. Herth, Kathrin Kahnert & The COSYCONET Study Group
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Summary:In patients with COPD, it has not been comprehensively assessed whether the predictive value of comorbidities for mortality differs between men and women. We therefore aimed to examine sex differences of COPD comorbidities in regard with prognosis by classifying comorbidities into a comorbidome related to extrapulmonary disorders and a pulmorbidome, referring to pulmonary disorders. The study population comprised 1044 women and 1531 men with the diagnosis of COPD from COSYCONET, among them 2175 of GOLD grades 1-4 and 400 at risk. Associations of comorbidities with mortality were studied using Cox regression analysis for men and women separately. During the follow-up (median 3.7 years) 59 women and 159 men died. In men, obesity, hypertension, coronary artery disease, liver cirrhosis, osteoporosis, kidney disease, anaemia and increased heart rate (HR) predict mortality, in women heart failure, hyperuricemia, mental disorders, kidney disease and increased HR (p < 0.05 each). Regarding the pulmorbidome, significant predictors in men were impairment in diffusion capacity and hyperinflation, in women asthma and hyperinflation. Similar results were obtained when repeating the analyses in GOLD 1-4 patients only. Gender differences should be considered in COPD risk assessment for a tailored approach towards the treatment of COPD.
Item Description:Gesehen am 21.07.2022
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-022-12828-8

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