Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients

AbstractObjectives. We investigated the long-term effect of efavirenz autoinduction on its plasma/peripheral blood mononuclear cell (PBMC) exposure and the CD4 count, and the importance of sex and pharmacogenetic variations.

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Bibliographic Details
Main Authors:	Habtewold, Abiy (Author) , Amogne, Wondwossen (Author) , Makonnen, Eyasu (Author) , Yimer, Getnet (Author) , Riedel, Klaus-Dieter (Author) , Ueda, Nobuhisa (Author) , Worku, Alemayehu (Author) , Haefeli, Walter E. (Author) , Lindquist, Lars (Author) , Aderaye, Getachew (Author) , Burhenne, Jürgen (Author) , Aklillu, Eleni (Author)
Format:	Article (Journal)
Language:	English
Published:	October 2011
In:	The journal of antimicrobial chemotherapy Year: 2011, Volume: 66, Issue: 10, Pages: 2350-2361
ISSN:	1460-2091
DOI:	10.1093/jac/dkr304
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/jac/dkr304 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/jac/article/66/10/2350/733406
Author Notes:	Abiy Habtewold, Wondwossen Amogne, Eyasu Makonnen, Getnet Yimer, Klaus-Dieter Riedel, Nobuhisa Ueda, Alemayehu Worku, Walter Emil Haefeli, Lars Lindquist, Getachew Aderaye, Jürgen Burhenne and Eleni Aklillu

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Summary:	AbstractObjectives. We investigated the long-term effect of efavirenz autoinduction on its plasma/peripheral blood mononuclear cell (PBMC) exposure and the CD4 count, and the importance of sex and pharmacogenetic variations.
Item Description:	Gesehen am 26.07.2022
Physical Description:	Online Resource
ISSN:	1460-2091
DOI:	10.1093/jac/dkr304