Association of circulating leukocyte telomere length with survival in patients with colorectal cancer
Introduction - Telomere shortening, as seen with aging, can cause chromosomal instability and promote cancer progression. We investigated the association between circulating telomere length and overall and disease-free survival in a sub-cohort of patients with colorectal cancer. - Methods - Baseline...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5 January 2022
|
| In: |
Journal of geriatric oncology
Year: 2022, Jahrgang: 13, Heft: 4, Pages: 480-485 |
| ISSN: | 1879-4076 |
| DOI: | 10.1016/j.jgo.2021.12.008 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jgo.2021.12.008 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1879406821002721 
|
| Verfasserangaben: | Svenja Pauleck, Biljana Gigic, Richard M. Cawthon, Jennifer Ose, Anita R. Peoples, Christy A. Warby, Jennifer A. Sinnott, Tengda Lin, Juergen Boehm, Petra Schrotz-King, Christopher I. Li, David Shibata, Erin M. Siegel, Jane C. Figueiredo, Adetunji T. Toriola, Martin Schneider, Alexis B. Ulrich, Albrecht Hoffmeister, Cornelia M. Ulrich, Sheetal Hardikar |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1811780563 | ||
| 003 | DE-627 | ||
| 005 | 20240416193918.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220727s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jgo.2021.12.008 |2 doi | |
| 035 | |a (DE-627)1811780563 | ||
| 035 | |a (DE-599)KXP1811780563 | ||
| 035 | |a (OCoLC)1341464326 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Pauleck, Svenja |d 1996- |e VerfasserIn |0 (DE-588)1263671586 |0 (DE-627)1811787754 |4 aut | |
| 245 | 1 | 0 | |a Association of circulating leukocyte telomere length with survival in patients with colorectal cancer |c Svenja Pauleck, Biljana Gigic, Richard M. Cawthon, Jennifer Ose, Anita R. Peoples, Christy A. Warby, Jennifer A. Sinnott, Tengda Lin, Juergen Boehm, Petra Schrotz-King, Christopher I. Li, David Shibata, Erin M. Siegel, Jane C. Figueiredo, Adetunji T. Toriola, Martin Schneider, Alexis B. Ulrich, Albrecht Hoffmeister, Cornelia M. Ulrich, Sheetal Hardikar |
| 264 | 1 | |c 5 January 2022 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.07.2022 | ||
| 520 | |a Introduction - Telomere shortening, as seen with aging, can cause chromosomal instability and promote cancer progression. We investigated the association between circulating telomere length and overall and disease-free survival in a sub-cohort of patients with colorectal cancer. - Methods - Baseline genomic DNA from blood leukocytes was extracted from N = 92 newly diagnosed stage I-IV patients with colorectal cancer enrolled at the ColoCare Study site in Heidelberg, Germany. Detailed information on clinicodemographic (including age) and lifestyle risk factors, and clinical outcomes (including recurrence and survival) was collected. Telomere length was measured in DNA using multiplex quantitative polymerase chain reaction. Kaplan Meier survival curves were generated comparing shorter to longer telomere lengths with log-rank testing. - Results - The mean T/S ratio for study patients was 0.5 (range: 0.3-0.9). Shorter telomeres were associated with older age at baseline. Patients with shorter telomeres experienced a worse overall and disease-free survival, although this association did not reach statistical significance. Kaplan-Meier survival curves for those with circulating telomere length below vs. above the median showed poorer overall (log-rank p = 0.31) and disease-free survival (long-rank p = 0.23). - Conclusions - Our results suggest that individuals with shorter telomeres, as seen with aging, may experience a worse overall and disease-free survival after colorectal cancer diagnosis. Larger sample sizes with longer follow-up are needed to further evaluate telomere length as a prognostic biomarker in colorectal cancer progression. | ||
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Disease-free survival | |
| 650 | 4 | |a Leukocyte telomere length | |
| 650 | 4 | |a Overall survival | |
| 700 | 1 | |a Gigić, Biljana |d 1978- |e VerfasserIn |0 (DE-588)1124096310 |0 (DE-627)877817561 |0 (DE-576)482295201 |4 aut | |
| 700 | 1 | |a Cawthon, Richard M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ose, Jennifer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peoples, Anita R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Warby, Christy A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sinnott, Jennifer A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lin, Tengda |e VerfasserIn |4 aut | |
| 700 | 1 | |a Boehm, Juergen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schrotz-King, Petra |e VerfasserIn |0 (DE-588)1078258066 |0 (DE-627)838209327 |0 (DE-576)450367118 |4 aut | |
| 700 | 1 | |a Li, Christopher I. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shibata, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siegel, Erin M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Figueiredo, Jane C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Toriola, Adetunji T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneider, Martin |d 1976- |e VerfasserIn |0 (DE-588)12390384X |0 (DE-627)706468147 |0 (DE-576)42325037X |4 aut | |
| 700 | 1 | |a Ulrich, Alexis |e VerfasserIn |0 (DE-588)1022952226 |0 (DE-627)717337847 |0 (DE-576)177315083 |4 aut | |
| 700 | 1 | |a Hoffmeister, Albrecht |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ulrich, Cornelia |d 1967- |e VerfasserIn |0 (DE-588)1045797030 |0 (DE-627)775130133 |0 (DE-576)399253289 |4 aut | |
| 700 | 1 | |a Hardikar, Sheetal |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of geriatric oncology |d Amsterdam [u.a.] : Elsevier Science, 2010 |g 13(2022), 4 vom: Mai, Seite 480-485 |h Online-Ressource |w (DE-627)627611915 |w (DE-600)2556813-9 |w (DE-576)336956584 |x 1879-4076 |7 nnas |a Association of circulating leukocyte telomere length with survival in patients with colorectal cancer |
| 773 | 1 | 8 | |g volume:13 |g year:2022 |g number:4 |g month:05 |g pages:480-485 |g extent:6 |a Association of circulating leukocyte telomere length with survival in patients with colorectal cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jgo.2021.12.008 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1879406821002721 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220727 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1045797030 |a Ulrich, Cornelia |m 1045797030:Ulrich, Cornelia |d 50000 |e 50000PU1045797030 |k 0/50000/ |p 19 | ||
| 998 | |g 1022952226 |a Ulrich, Alexis |m 1022952226:Ulrich, Alexis |d 50000 |e 50000PU1022952226 |k 0/50000/ |p 17 | ||
| 998 | |g 12390384X |a Schneider, Martin |m 12390384X:Schneider, Martin |d 910000 |d 910200 |e 910000PS12390384X |e 910200PS12390384X |k 0/910000/ |k 1/910000/910200/ |p 16 | ||
| 998 | |g 1078258066 |a Schrotz-King, Petra |m 1078258066:Schrotz-King, Petra |p 10 | ||
| 998 | |g 1124096310 |a Gigić, Biljana |m 1124096310:Gigić, Biljana |d 910000 |d 910200 |e 910000PG1124096310 |e 910200PG1124096310 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 999 | |a KXP-PPN1811780563 |e 4173062176 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title":"Association of circulating leukocyte telomere length with survival in patients with colorectal cancer","title_sort":"Association of circulating leukocyte telomere length with survival in patients with colorectal cancer"}],"physDesc":[{"extent":"6 S."}],"note":["Gesehen am 27.07.2022"],"name":{"displayForm":["Svenja Pauleck, Biljana Gigic, Richard M. Cawthon, Jennifer Ose, Anita R. Peoples, Christy A. Warby, Jennifer A. Sinnott, Tengda Lin, Juergen Boehm, Petra Schrotz-King, Christopher I. Li, David Shibata, Erin M. Siegel, Jane C. Figueiredo, Adetunji T. Toriola, Martin Schneider, Alexis B. Ulrich, Albrecht Hoffmeister, Cornelia M. Ulrich, Sheetal Hardikar"]},"person":[{"given":"Svenja","family":"Pauleck","display":"Pauleck, Svenja","role":"aut"},{"given":"Biljana","family":"Gigić","display":"Gigić, Biljana","role":"aut"},{"family":"Cawthon","display":"Cawthon, Richard M.","role":"aut","given":"Richard M."},{"given":"Jennifer","role":"aut","display":"Ose, Jennifer","family":"Ose"},{"given":"Anita R.","display":"Peoples, Anita R.","family":"Peoples","role":"aut"},{"role":"aut","display":"Warby, Christy A.","family":"Warby","given":"Christy A."},{"given":"Jennifer A.","role":"aut","display":"Sinnott, Jennifer A.","family":"Sinnott"},{"role":"aut","family":"Lin","display":"Lin, Tengda","given":"Tengda"},{"given":"Juergen","display":"Boehm, Juergen","family":"Boehm","role":"aut"},{"given":"Petra","role":"aut","display":"Schrotz-King, Petra","family":"Schrotz-King"},{"role":"aut","display":"Li, Christopher I.","family":"Li","given":"Christopher I."},{"given":"David","family":"Shibata","display":"Shibata, David","role":"aut"},{"display":"Siegel, Erin M.","family":"Siegel","role":"aut","given":"Erin M."},{"given":"Jane C.","role":"aut","family":"Figueiredo","display":"Figueiredo, Jane C."},{"role":"aut","family":"Toriola","display":"Toriola, Adetunji T.","given":"Adetunji T."},{"family":"Schneider","display":"Schneider, Martin","role":"aut","given":"Martin"},{"given":"Alexis","role":"aut","display":"Ulrich, Alexis","family":"Ulrich"},{"given":"Albrecht","role":"aut","family":"Hoffmeister","display":"Hoffmeister, Albrecht"},{"given":"Cornelia","display":"Ulrich, Cornelia","family":"Ulrich","role":"aut"},{"given":"Sheetal","role":"aut","family":"Hardikar","display":"Hardikar, Sheetal"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"note":["Gesehen am 24.02.11"],"title":[{"title":"Journal of geriatric oncology","subtitle":"cancer and aging research","title_sort":"Journal of geriatric oncology"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"id":{"zdb":["2556813-9"],"eki":["627611915"],"issn":["1879-4076"]},"origin":[{"publisher":"Elsevier Science","dateIssuedDisp":"2010-","dateIssuedKey":"2010","publisherPlace":"Amsterdam [u.a.]"}],"pubHistory":["1.2010 -"],"disp":"Association of circulating leukocyte telomere length with survival in patients with colorectal cancerJournal of geriatric oncology","part":{"pages":"480-485","volume":"13","text":"13(2022), 4 vom: Mai, Seite 480-485","year":"2022","extent":"6","issue":"4"},"recId":"627611915","type":{"bibl":"periodical","media":"Online-Ressource"}}],"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"5 January 2022"}],"id":{"doi":["10.1016/j.jgo.2021.12.008"],"eki":["1811780563"]},"recId":"1811780563"} | ||
| SRT | |a PAULECKSVEASSOCIATIO5202 | ||