Time course and reaction types of serum IGF-1 and its relationship to BMI and leptin regarding inpatients with anorexia nervosa
Objective - Anorexia nervosa (AN) is a severe mental disorder that is characterized by restriction of energy intake, low weight, and endocrine abnormalities. One of the known endocrine changes in relation to underweight is in the GH/IGF-I axis. The aim of the study was (a) to investigate longitudina...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 May 2022
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| In: |
Growth hormone & IGF research
Year: 2022, Volume: 64, Pages: 1-5 |
| ISSN: | 1532-2238 |
| DOI: | 10.1016/j.ghir.2022.101470 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ghir.2022.101470 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1096637422000272 
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| Author Notes: | Christiane Hellwig-Walter, Maik Brune, Dieter Schellberg, Magdalena Buckert, Daniela Wesche, Ulrich Cuntz, Hans-Christoph Friederich, Beate Wild |
| Summary: | Objective - Anorexia nervosa (AN) is a severe mental disorder that is characterized by restriction of energy intake, low weight, and endocrine abnormalities. One of the known endocrine changes in relation to underweight is in the GH/IGF-I axis. The aim of the study was (a) to investigate longitudinal characteristics of the IGF-I-change during therapy and weight gain in adult AN, (b) to determine relationships between IGF-I and leptin, (c) to characterize patients with weak and pronounced hormonal reactions to underweight. - Design - Data was assessed from 19 AN patients. Over the first two months, serum IGF-I concentrations were assessed on a weekly basis; thereafter on a monthly basis. The trend of IGF-I values over time was analyzed using individual growth models. - Results - In total, n = 177 IGF-I measurements were analyzed. IGF-I increased significantly dependent on BMI (slope = 20.81, p < 0.001), not modulated by duration of disease. The increase in IGF-I was significantly related to the increase in leptin concentrations over time (slope = 15.57, p < 0.001). Patients with a weaker hormonal reaction to underweight were significantly older compared to patients with a pronounced hormonal reaction (t(17) = 3.07, p = 0.007). - Conclusions - During treatment, IGF-I change is clearly related to BMI as well as to leptin. Age appears to be associated with the IGF-I response to underweight. |
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| Item Description: | Gesehen am 27.07.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1532-2238 |
| DOI: | 10.1016/j.ghir.2022.101470 |