Fas (APO-1/CD95) in inflammatory CNS diseases: intrathecal release in bacterial meningitis
Release of Fas (APO-1, CD95), a type L-membrane protein which plays a crucial role in cytokine-mediated apoptosis was investigated in bacterial meningitis, viral meningoencephalitis and multiple sclerosis in vivo. After correction for bloodbrain-CSF-disruption, significantly increased intrathecal re...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 January 1999
|
| In: |
Journal of neuroimmunology
Year: 1999, Volume: 93, Issue: 1-2, Pages: 122-125 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/s0165-5728(98)00210-0 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/s0165-5728(98)00210-0
|
| Author Notes: | K. Fassbender, C. Eschenfelder, M. Hennerici |
| Summary: | Release of Fas (APO-1, CD95), a type L-membrane protein which plays a crucial role in cytokine-mediated apoptosis was investigated in bacterial meningitis, viral meningoencephalitis and multiple sclerosis in vivo. After correction for bloodbrain-CSF-disruption, significantly increased intrathecal release of Fas was demonstrated exclusively in bacterial meningitis arguing for an apoptotic cell death of granulocytes in the subarachnoidal space aimed to self-limit inflammatory host response. |
|---|---|
| Item Description: | Gesehen am 27.07.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/s0165-5728(98)00210-0 |