Fas (APO-1/CD95) in inflammatory CNS diseases: intrathecal release in bacterial meningitis
Release of Fas (APO-1, CD95), a type L-membrane protein which plays a crucial role in cytokine-mediated apoptosis was investigated in bacterial meningitis, viral meningoencephalitis and multiple sclerosis in vivo. After correction for bloodbrain-CSF-disruption, significantly increased intrathecal re...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 January 1999
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| In: |
Journal of neuroimmunology
Year: 1999, Jahrgang: 93, Heft: 1-2, Pages: 122-125 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/s0165-5728(98)00210-0 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/s0165-5728(98)00210-0
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| Verfasserangaben: | K. Fassbender, C. Eschenfelder, M. Hennerici |
| Zusammenfassung: | Release of Fas (APO-1, CD95), a type L-membrane protein which plays a crucial role in cytokine-mediated apoptosis was investigated in bacterial meningitis, viral meningoencephalitis and multiple sclerosis in vivo. After correction for bloodbrain-CSF-disruption, significantly increased intrathecal release of Fas was demonstrated exclusively in bacterial meningitis arguing for an apoptotic cell death of granulocytes in the subarachnoidal space aimed to self-limit inflammatory host response. |
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| Beschreibung: | Gesehen am 27.07.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/s0165-5728(98)00210-0 |