Pre-transplant type 2 diabetes mellitus is associated with higher graft failure and increased 5-year mortality after heart transplantation
AimsCardiac transplant recipients often suffer from type 2 diabetes mellitus (T2DM) but its influence on graft failure and post-transplant mortality remains unknown. The aim of this study was to investigate the long-term effects of pre-transplant T2DM in patients after heart transplantation (HTX).Me...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 June 2022
|
| In: |
Frontiers in Cardiovascular Medicine
Year: 2022, Jahrgang: 9, Pages: 1-12 |
| ISSN: | 2297-055X |
| DOI: | 10.3389/fcvm.2022.890359 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fcvm.2022.890359 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fcvm.2022.890359 
|
| Verfasserangaben: | Rasmus Rivinius, Carolin Gralla, Matthias Helmschrott, Fabrice F. Darche, Philipp Ehlermann, Tom Bruckner, Wiebke Sommer, Gregor Warnecke, Stefan Kopf, Julia Szendroedi, Norbert Frey and Lars P. Kihm |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1811959792 | ||
| 003 | DE-627 | ||
| 005 | 20230427152914.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220729s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fcvm.2022.890359 |2 doi | |
| 035 | |a (DE-627)1811959792 | ||
| 035 | |a (DE-599)KXP1811959792 | ||
| 035 | |a (OCoLC)1341464590 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rivinius, Rasmus |d 1986- |e VerfasserIn |0 (DE-588)1071009834 |0 (DE-627)825504309 |0 (DE-576)432876103 |4 aut | |
| 245 | 1 | 0 | |a Pre-transplant type 2 diabetes mellitus is associated with higher graft failure and increased 5-year mortality after heart transplantation |c Rasmus Rivinius, Carolin Gralla, Matthias Helmschrott, Fabrice F. Darche, Philipp Ehlermann, Tom Bruckner, Wiebke Sommer, Gregor Warnecke, Stefan Kopf, Julia Szendroedi, Norbert Frey and Lars P. Kihm |
| 264 | 1 | |c 09 June 2022 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.07.2022 | ||
| 520 | |a AimsCardiac transplant recipients often suffer from type 2 diabetes mellitus (T2DM) but its influence on graft failure and post-transplant mortality remains unknown. The aim of this study was to investigate the long-term effects of pre-transplant T2DM in patients after heart transplantation (HTX).MethodsThis study included a total of 376 adult patients who received HTX at Heidelberg Heart Center between 01/01/2000 and 01/10/2016. HTX recipients were stratified by diagnosis of T2DM at the time of HTX. Patients with T2DM were further subdivided by hemoglobin A1c (HbA1c ≥ 7.0%). Analysis included donor and recipient data, immunosuppressive drugs, concomitant medications, post-transplant mortality, and causes of death. Five-year post-transplant mortality was further assessed by multivariate analysis (Cox regression) and Kaplan-Meier estimator.ResultsAbout one-third of all HTX recipients had T2DM (121 of 376 [32.2%]). Patients with T2DM showed an increased 5-year post-transplant mortality (41.3% versus 29.8%; P = 0.027) and had a higher percentage of death due to graft failure (14.9% versus 7.8%; P = 0.035). Multivariate analysis showed T2DM (HR: 1.563; 95% CI: 1.053-2.319; P = 0.027) as an independent risk factor for 5-year mortality after HTX. Kaplan-Meier analysis showed a significantly better 5-year post-transplant survival of patients with T2DM and a HbA1c < 7.0% than patients with T2DM and a HbA1c ≥ 7.0% (68.7% versus 46.3%; P = 0.008) emphasizing the clinical relevance of a well-controlled T2DM in HTX recipients.ConclusionPre-transplant T2DM is associated with higher graft failure and increased 5-year mortality after HTX. | ||
| 700 | 1 | |a Gralla, Carolin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Helmschrott, Matthias |d 1986- |e VerfasserIn |0 (DE-588)1063822068 |0 (DE-627)812634187 |0 (DE-576)423257323 |4 aut | |
| 700 | 1 | |a Darche, Fabrice Fernand |d 1986- |e VerfasserIn |0 (DE-588)1074849833 |0 (DE-627)832587044 |0 (DE-576)442994982 |4 aut | |
| 700 | 1 | |a Ehlermann, Philipp |d 1969- |e VerfasserIn |0 (DE-588)121563812 |0 (DE-627)705540855 |0 (DE-576)292774761 |4 aut | |
| 700 | 1 | |a Bruckner, Thomas |d 1956- |e VerfasserIn |0 (DE-588)136046215 |0 (DE-627)574429298 |0 (DE-576)300798768 |4 aut | |
| 700 | 1 | |a Sommer, Wiebke |d 1983- |e VerfasserIn |0 (DE-588)140917918 |0 (DE-627)623126710 |0 (DE-576)321354729 |4 aut | |
| 700 | 1 | |a Warnecke, Gregor |d 1974- |e VerfasserIn |0 (DE-588)125001517 |0 (DE-627)370699629 |0 (DE-576)294612823 |4 aut | |
| 700 | 1 | |a Kopf, Stefan |d 1978- |e VerfasserIn |0 (DE-588)1013047516 |0 (DE-627)663343453 |0 (DE-576)346399025 |4 aut | |
| 700 | 1 | |a Szendrödi, Julia |e VerfasserIn |0 (DE-588)1226436463 |0 (DE-627)1747448249 |4 aut | |
| 700 | 1 | |a Frey, Norbert |e VerfasserIn |0 (DE-588)141244976 |0 (DE-627)625824075 |0 (DE-576)322969514 |4 aut | |
| 700 | 1 | |a Kihm, Lars Philipp |d 1978- |e VerfasserIn |0 (DE-588)131796550 |0 (DE-627)514262087 |0 (DE-576)298757346 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in Cardiovascular Medicine |d Lausanne : Frontiers Media, 2014 |g 9(2022), Artikel-ID 890359, Seite 1-12 |h Online-Ressource |w (DE-627)793951607 |w (DE-600)2781496-8 |w (DE-576)412047004 |x 2297-055X |7 nnas |a Pre-transplant type 2 diabetes mellitus is associated with higher graft failure and increased 5-year mortality after heart transplantation |
| 773 | 1 | 8 | |g volume:9 |g year:2022 |g elocationid:890359 |g pages:1-12 |g extent:12 |a Pre-transplant type 2 diabetes mellitus is associated with higher graft failure and increased 5-year mortality after heart transplantation |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fcvm.2022.890359 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fcvm.2022.890359 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220729 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 131796550 |a Kihm, Lars Philipp |m 131796550:Kihm, Lars Philipp |d 910000 |d 910100 |d 50000 |e 910000PK131796550 |e 910100PK131796550 |e 50000PK131796550 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 12 |y j | ||
| 998 | |g 141244976 |a Frey, Norbert |m 141244976:Frey, Norbert |d 910000 |d 910100 |e 910000PF141244976 |e 910100PF141244976 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 1226436463 |a Szendrödi, Julia |m 1226436463:Szendrödi, Julia |d 910000 |d 910100 |e 910000PS1226436463 |e 910100PS1226436463 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 1013047516 |a Kopf, Stefan |m 1013047516:Kopf, Stefan |d 910000 |d 910100 |e 910000PK1013047516 |e 910100PK1013047516 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 125001517 |a Warnecke, Gregor |m 125001517:Warnecke, Gregor |d 910000 |d 910200 |e 910000PW125001517 |e 910200PW125001517 |k 0/910000/ |k 1/910000/910200/ |p 8 | ||
| 998 | |g 140917918 |a Sommer, Wiebke |m 140917918:Sommer, Wiebke |d 910000 |d 910200 |d 50000 |e 910000PS140917918 |e 910200PS140917918 |e 50000PS140917918 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 7 | ||
| 998 | |g 136046215 |a Bruckner, Thomas |m 136046215:Bruckner, Thomas |p 6 | ||
| 998 | |g 121563812 |a Ehlermann, Philipp |m 121563812:Ehlermann, Philipp |d 910000 |d 910100 |e 910000PE121563812 |e 910100PE121563812 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1074849833 |a Darche, Fabrice Fernand |m 1074849833:Darche, Fabrice Fernand |d 910000 |d 910100 |e 910000PD1074849833 |e 910100PD1074849833 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1063822068 |a Helmschrott, Matthias |m 1063822068:Helmschrott, Matthias |d 910000 |d 910100 |e 910000PH1063822068 |e 910100PH1063822068 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1071009834 |a Rivinius, Rasmus |m 1071009834:Rivinius, Rasmus |d 910000 |d 910100 |d 50000 |e 910000PR1071009834 |e 910100PR1071009834 |e 50000PR1071009834 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1811959792 |e 4173699484 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 29.07.2022"],"recId":"1811959792","id":{"eki":["1811959792"],"doi":["10.3389/fcvm.2022.890359"]},"title":[{"title":"Pre-transplant type 2 diabetes mellitus is associated with higher graft failure and increased 5-year mortality after heart transplantation","title_sort":"Pre-transplant type 2 diabetes mellitus is associated with higher graft failure and increased 5-year mortality after heart transplantation"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"09 June 2022"}],"language":["eng"],"relHost":[{"pubHistory":["2014 -"],"titleAlt":[{"title":"FCVM"},{"title":"Front. Cardiovasc. Med"}],"recId":"793951607","part":{"volume":"9","text":"9(2022), Artikel-ID 890359, Seite 1-12","pages":"1-12","extent":"12","year":"2022"},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"publisher":"Frontiers Media","publisherPlace":"Lausanne","dateIssuedKey":"2014","dateIssuedDisp":"2014-"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Pre-transplant type 2 diabetes mellitus is associated with higher graft failure and increased 5-year mortality after heart transplantationFrontiers in Cardiovascular Medicine","note":["Gesehen am 04.06.20"],"id":{"zdb":["2781496-8"],"eki":["793951607"],"issn":["2297-055X"]},"title":[{"title_sort":"Frontiers in Cardiovascular Medicine","title":"Frontiers in Cardiovascular Medicine"}]}],"physDesc":[{"extent":"12 S."}],"person":[{"family":"Rivinius","roleDisplay":"VerfasserIn","given":"Rasmus","display":"Rivinius, Rasmus","role":"aut"},{"family":"Gralla","roleDisplay":"VerfasserIn","display":"Gralla, Carolin","role":"aut","given":"Carolin"},{"family":"Helmschrott","roleDisplay":"VerfasserIn","given":"Matthias","display":"Helmschrott, Matthias","role":"aut"},{"given":"Fabrice Fernand","role":"aut","display":"Darche, Fabrice Fernand","family":"Darche","roleDisplay":"VerfasserIn"},{"given":"Philipp","role":"aut","display":"Ehlermann, Philipp","roleDisplay":"VerfasserIn","family":"Ehlermann"},{"family":"Bruckner","roleDisplay":"VerfasserIn","role":"aut","display":"Bruckner, Thomas","given":"Thomas"},{"roleDisplay":"VerfasserIn","family":"Sommer","role":"aut","display":"Sommer, Wiebke","given":"Wiebke"},{"family":"Warnecke","roleDisplay":"VerfasserIn","given":"Gregor","display":"Warnecke, Gregor","role":"aut"},{"given":"Stefan","role":"aut","display":"Kopf, Stefan","family":"Kopf","roleDisplay":"VerfasserIn"},{"family":"Szendrödi","roleDisplay":"VerfasserIn","role":"aut","display":"Szendrödi, Julia","given":"Julia"},{"display":"Frey, Norbert","role":"aut","given":"Norbert","family":"Frey","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Kihm","given":"Lars Philipp","display":"Kihm, Lars Philipp","role":"aut"}],"name":{"displayForm":["Rasmus Rivinius, Carolin Gralla, Matthias Helmschrott, Fabrice F. Darche, Philipp Ehlermann, Tom Bruckner, Wiebke Sommer, Gregor Warnecke, Stefan Kopf, Julia Szendroedi, Norbert Frey and Lars P. Kihm"]}} | ||
| SRT | |a RIVINIUSRAPRETRANSPL0920 | ||