Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production

The antimalarial agent artesunate (ART) activates programmed cell death (PCD) in cancer cells in a manner dependent on the presence of iron and the generation of reactive oxygen species. In malaria parasites, ART cytotoxicity originates from interactions with heme-derived iron within the food vacuol...

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Bibliographic Details

Main Authors:	Hamacher-Brady, Anne (Author) , Stein, Henning Alexander (Author) , Turschner, Simon (Author) , Toegel, Ina (Author) , Mora, Rodrigo (Author) , Jennewein, Nina (Author) , Efferth, Thomas (Author) , Eils, Roland (Author) , Brady, Nathan R. (Author)
Format:	Article (Journal)
Language:	English
Published:	February 25, 2011
In:	The journal of biological chemistry Year: 2011, Volume: 286, Issue: 8, Pages: 6587-6601
ISSN:	1083-351X
DOI:	10.1074/jbc.M110.210047
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1074/jbc.M110.210047 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0021925820520346 Verlag, lizenzpflichtig, Volltext: https://www.jbc.org/article/S0021-9258(20)52034-6/fulltext
Author Notes:	Anne Hamacher-Brady, Henning A. Stein, Simon Turschner, Ina Toegel, Rodrigo Mora, Nina Jennewein, Thomas Efferth, Roland Eils, and Nathan R. Brady