Cover Image

Pathologic responses in oligometastatic NSCLC patients treated with neoadjuvant immune checkpoint blockade with and without chemotherapy followed by surgery

Objectives - Immune checkpoint inhibitors (ICI) have significantly improved outcome of patients with advanced NSCLC and recently also showed benefit in early-stage disease. Patients with oligometastatic disease (OMD) harbor limited metastases, resectable primary tumors and derive benefit from treatm...

Full description

Saved in:
Bibliographic Details
Main Authors: Boch, Tobias (Author) , Frost, Nikolaj (Author) , Sommer, Linna (Author) , Overbeck, Tobias (Author) , Michaeli, Christoph T. (Author) , Szuszies, Chrisoph J. (Author) , Rieckmann, Lisa-Marie (Author) , Beumer, Niklas (Author) , Imbusch, Charles (Author) , Winter, Hauke (Author) , Thomas, Michael (Author) , Roeper, Julia (Author) , Janning, Melanie (Author) , Griesinger, Frank (Author) , Wermke, Martin (Author) , Loges, Sonja (Author)
Format: Article (Journal)
Language:English
Published: 2022
In: Lung cancer
Year: 2022, Volume: 164, Pages: 46-51
ISSN:1872-8332
DOI:10.1016/j.lungcan.2021.11.009
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.lungcan.2021.11.009
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0169500221006024
Get full text
Author Notes:Tobias Boch, Nikolaj Frost, Linna Sommer, Tobias R. Overbeck, Christoph T. Michaeli, Chrisoph J. Szuszies, Lisa-Marie Rieckmann, Niklas Beumer, Charles D. Imbusch, Hauke Winter, Michael Thomas, Julia Roeper, Melanie Janning, Frank Griesinger, Martin Wermke, Sonja Loges
Description
Summary:Objectives - Immune checkpoint inhibitors (ICI) have significantly improved outcome of patients with advanced NSCLC and recently also showed benefit in early-stage disease. Patients with oligometastatic disease (OMD) harbor limited metastases, resectable primary tumors and derive benefit from treatment with multimodal locally ablative and systemic therapy approaches. Nothing is known about feasibility and efficacy of neoadjuvant ICI in this setting. - Material and methods - We here provide data from a multicenter retrospective study comprising 13 patients with NSCLC and OMD (≤3 distant metastases) from 5 university medical centers in Germany who have been treated with neoadjuvant ICI alone (n = 4) or in combination with chemotherapy (CT) (n = 9) prior to resection of the primary tumor. We analyzed complete (pCR) and major pathological remission (MPR) rates. - Results - These data show that neoadjuvant immunotherapy applied mostly in combination with CT results in high rates of pCR and MPR (54 and 69%, respectively). Up to now, 85% of patients are free of progression with a median follow-up of 9 months (3-28 months). Single cell RNASeq analysis of tumor tissue from one patient treated with CT-ICI indicates a strong predominance of adaptive immune cell populations over a small minority of epithelial (tumor) cells. - Conclusion - Neoadjuvant ICI with or without CT is a promising therapeutic concept in patients with OMD.
Item Description:Available online 23 November 2021
Gesehen am 03.08.2022
Physical Description:Online Resource
ISSN:1872-8332
DOI:10.1016/j.lungcan.2021.11.009

Similar Items