[FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells
We demonstrate the cytotoxic potential of the Schiff base iron complex [FeIII(salophene)Cl] in vitro and ex vivo and illustrate its ability to overcome multiple drug resistance in vincristine and daunorubicine resistant leukemic cells (Nalm-6). Treatment of lymphoma cells (BJAB) with [FeIII(salophen...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| In: |
Leukemia research
Year: 2011, Jahrgang: 35, Heft: 3, Pages: 387-393 |
| ISSN: | 1873-5835 |
| DOI: | 10.1016/j.leukres.2010.11.007 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.leukres.2010.11.007 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0145212610005369 
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| Verfasserangaben: | Soo-Young Lee, Annegret Hille, Igor Kitanovic, Patrick Jesse, Günter Henze, Stefan Wölfl, Ronald Gust, Aram Prokop |
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| 520 | |a We demonstrate the cytotoxic potential of the Schiff base iron complex [FeIII(salophene)Cl] in vitro and ex vivo and illustrate its ability to overcome multiple drug resistance in vincristine and daunorubicine resistant leukemic cells (Nalm-6). Treatment of lymphoma cells (BJAB) with [FeIII(salophene)Cl] led to the exclusion of unspecific necrosis, a concentration-dependent inhibition of proliferation and a specific apoptotic cell death. We further detected a significant loss of the mitochondrial membrane potential in lymphoma cells and an up- and downregulation of various apoptosis relevant genes, respectively, indicating the involvement of the intrinsic mitochondrial pathway. | ||
| 650 | 4 | |a DNA fragmentation | |
| 650 | 4 | |a LDH release | |
| 650 | 4 | |a Mitochondrial apoptosis | |
| 650 | 4 | |a Resistance overcome | |
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