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Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction

In human cells, separation of the centrosomes and formation of a bipolar spindle are essential for correct chromosome segregation [1]. During interphase, centrosomes are joined together by the linker proteins C-Nap1 and rootletin [2, 3, 4]. At the onset of mitosis, these linker proteins are phosphor...

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Hauptverfasser: Mardin, Balca (VerfasserIn) , Agircan, Fikret Gürkan (VerfasserIn) , Kellner, Cornelia (VerfasserIn) , Schiebel, Elmar (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 30, 2011
In: Current biology
Year: 2011, Jahrgang: 21, Heft: 13, Pages: 1145-1151
ISSN:1879-0445
DOI:10.1016/j.cub.2011.05.047
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cub.2011.05.047
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0960982211006051
Volltext
Verfasserangaben:Balca R. Mardin, Fikret G. Agircan, Cornelia Lange, and Elmar Schiebel

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520 |a In human cells, separation of the centrosomes and formation of a bipolar spindle are essential for correct chromosome segregation [1]. During interphase, centrosomes are joined together by the linker proteins C-Nap1 and rootletin [2, 3, 4]. At the onset of mitosis, these linker proteins are phosphorylated and displaced from centrosomes by the Nek2A kinase, which is regulated by two Hippo pathway components, Mst2 kinase and the scaffold protein hSav1. The kinesin-5 motor protein Eg5 promotes centrosome separation in a parallel pathway to Nek2A [5]. Here, we report that Polo-like kinase 1 (Plk1) functions upstream of the Mst2-Nek2A kinase module in centrosome disjunction as well as being important for Eg5 localization at centrosomes. Plk1 regulates Mst2-Nek2A-induced centrosome disjunction by phosphorylating Mst2. The absence of Plk1 phosphorylation of Mst2 promotes assembly of Nek2A-PP1γ-Mst2 complexes, in which PP1γ counteracts Nek2A kinase activity. In contrast, Plk1 phosphorylation of Mst2 prevents PP1γ binding to Mst2-Nek2A, allowing Nek2A activity to promote centrosome disjunction. We propose that centrosome disjunction is regulated by Plk1, providing a well-balanced control between the counteracting Nek2A and PP1γ activities on the centrosome linker. 
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