HMGA2 and p14Arf: major roles in cellular senescence of fibroids and therapeutic implications
Aim: To address the influence of genes involved in stem cell self-renewal and senescence on the growth of leiomyoma cells in vitro and to explore possible therapeutic implications of a targeted disruption of the p53-murine double minute 2 (MDM2) interaction. Materials and Methods: Gene expression st...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 15, 2011
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| In: |
Anticancer research
Year: 2011, Jahrgang: 31, Heft: 3, Pages: 753-761 |
| ISSN: | 1791-7530 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/31/3/753
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| Verfasserangaben: | Dominique Nadine Markowski, Burkhard Maria Helmke, Gazanfer Belge, Rolf Nimzyk, Sabine Bartnitzke, Ulrich Deichert and Jörn Bullerdiek |
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| 520 | |a Aim: To address the influence of genes involved in stem cell self-renewal and senescence on the growth of leiomyoma cells in vitro and to explore possible therapeutic implications of a targeted disruption of the p53-murine double minute 2 (MDM2) interaction. Materials and Methods: Gene expression studies (qRT-PCR) of fibroid tissue and cells; β-galactosidase stain and qRT-PCR after antagonizing MDM2. Results: In fibroid cells, expression of HMGA2 decreased with passaging while that of p14Arf increased. Expression of these markers significantly positively, and negatively, respectively, influenced proliferation. Administration of nutlin-3, an MDM2 antagonist, induced cellular senescence and increased the expression of BAX. This, along with a significant correlation between p14Arf and BAX expression in native fibroids, suggests that p14Arf triggers senescence as well as apoptosis. Conclusion: p14Arf and HMGA2 seem to play a pivotal role in controlling the growth of fibroid cells. Antagonizing MDM2 induces senescence, as well as apoptosis, and may offer a chance to treat fibroids. | ||
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| 650 | 4 | |a fibroid cells | |
| 650 | 4 | |a HMGA2 | |
| 650 | 4 | |a Leiomyoma | |
| 650 | 4 | |a MDM2 antagonists | |
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| 700 | 1 | |a Deichert, Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bullerdiek, Jörn |e VerfasserIn |4 aut | |
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