Renal salt wasting as part of dysautonomia in Guillain-Barré syndrome

Cerebral salt-wasting syndrome and the syndrome of inappropriate antidiuresis (SIAD) are the most important causes of non-iatrogenic hyponatraemia that can significantly complicate various brain diseases. Salt wasting without an underlying CNS disease may have been disregarded so far by clinicians a...

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Hauptverfasser: Lenhard, Thorsten (VerfasserIn) , Grimm, Christiane (VerfasserIn) , Ringleb, Peter A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2011
In: Journal of neurology, neurosurgery, and psychiatry
Year: 2011, Jahrgang: 82, Heft: 9, Pages: 1051-1053
ISSN:1468-330X
DOI:10.1136/jnnp.2009.192369
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jnnp.2009.192369
Verlag, lizenzpflichtig, Volltext: https://jnnp.bmj.com/content/82/9/1051
Volltext
Verfasserangaben:T. Lenhard, C. Grimm, P.A. Ringleb

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520 |a Cerebral salt-wasting syndrome and the syndrome of inappropriate antidiuresis (SIAD) are the most important causes of non-iatrogenic hyponatraemia that can significantly complicate various brain diseases. Salt wasting without an underlying CNS disease may have been disregarded so far by clinicians and has been described as renal salt-wasting (RSW) in patients as drug side effect (eg, cisplatin), in older people with various common diseases (eg, hip fracture, pulmonary infections) and other sporadic conditions. In Guillain-Barré Syndrome (GBS), however, hyponatraemia has been described mainly as SIAD. However, symptoms of hyponatraemia rarely develop in GBS. Here, we report on a woman with GBS with dominant symptoms of dysautonomia and moderate severe hyponatraemia. We could identify RSW as part of the autonomic dysfunction that significantly contributed to disease worsening. 
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