Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma
Abstract Obesity is a well-known risk factor for the development of secondary complications such as type 2 diabetes. However, only a part of the obese population develops secondary metabolic disorders. Here, we identify the transcription factor retinoid-related orphan receptor gamma (ROR?) as a nega...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 August 2011
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| In: |
EMBO molecular medicine
Year: 2011, Jahrgang: 3, Heft: 11, Pages: 637-651 |
| ISSN: | 1757-4684 |
| DOI: | 10.1002/emmm.201100172 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/emmm.201100172 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1002/emmm.201100172 
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| Verfasserangaben: | Bettina Meissburger, Jozef Ukropec, Eva Roeder, Nigel Beaton, Matthias Geiger, Daniel Teupser, Burcak Civan, Wolfgang Langhans, Peter P. Nawroth, Daniela Gasperikova, Gottfried Rudofsky, Christian Wolfrum |
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| 245 | 1 | 0 | |a Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma |c Bettina Meissburger, Jozef Ukropec, Eva Roeder, Nigel Beaton, Matthias Geiger, Daniel Teupser, Burcak Civan, Wolfgang Langhans, Peter P. Nawroth, Daniela Gasperikova, Gottfried Rudofsky, Christian Wolfrum |
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| 520 | |a Abstract Obesity is a well-known risk factor for the development of secondary complications such as type 2 diabetes. However, only a part of the obese population develops secondary metabolic disorders. Here, we identify the transcription factor retinoid-related orphan receptor gamma (ROR?) as a negative regulator of adipocyte differentiation through expression of its newly identified target gene matrix metalloproteinase 3. In vivo differentiation of adipocyte progenitor cells from Ror?-deficient mice is enhanced and obese Ror??/? mice show decreased adipocyte sizes. These small adipocytes are highly insulin sensitive, leading to an improved control of circulating free fatty acids. Ultimately, Ror??/? mice are protected from hyperglycemia and insulin resistance in the state of obesity. In adipose stromal-vascular fraction from obese human subjects, Ror? expression is correlated with adipocyte size and negatively correlated with adipogenesis and insulin sensitivity. Taken together, our findings identify ROR? as a factor, which controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. ROR? might therefore serve as a novel pharmaceutical target to treat obesity-associated insulin resistance. | ||
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