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Classification of skin sensitizing substances: a comparison between approaches used by the DFG-MAK Commission and the European Union legislation

A systematic classification of substances (or mixtures of substances) with regard to various toxicological endpoints is a prerequisite for the implementation of occupational safety strategies. As its principal task the “Commission for the Investigation of Health Hazards of Chemical Compounds in the...

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Main Authors: Lessmann, Holger (Author) , Uter, W. (Author) , Diepgen, Thomas L. (Author) , Drexler, H. (Author) , Fartasch, M. (Author) , Greim, H. (Author) , Hartwig, A. (Author) , Kreis, P. (Author) , Löser, E. (Author) , Merget, R. (Author) , Merk, H. (Author) , Nowak, D. (Author) , Rothe, A. (Author) , Stropp, G. (Author) , Schnuch, A. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Regulatory toxicology and pharmacology
Year: 2011, Volume: 61, Issue: 1, Pages: 1-8
ISSN:1096-0295
DOI:10.1016/j.yrtph.2011.06.008
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.yrtph.2011.06.008
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0273230011001474
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Author Notes:H. Lessmann, W. Uter, T. L. Diepgen, H. Drexler, M. Fartasch, H. Greim, A. Hartwig, P. Kreis, E. Löser, R. Merget, H. Merk, D. Nowak, A. Rothe, G. Stropp, A. Schnuch
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Summary:A systematic classification of substances (or mixtures of substances) with regard to various toxicological endpoints is a prerequisite for the implementation of occupational safety strategies. As its principal task the “Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area” of the “Deutsche Forschungsgemeinschaft” (DFG-MAK Commission) derives and recommends maximum workplace concentrations and biological tolerance values (MAK and BAT values) based exclusively on scientific arguments. Several endpoints are evaluated separately in detail, e.g. carcinogenicity, risks during pregnancy, germ cell mutagenicity or contribution to systemic toxicity after cutaneous absorption. Skin- and airway sensitization is also considered; the present paper focuses on these two endpoints.
Item Description:Gesehen am 17.08.2022
Physical Description:Online Resource
ISSN:1096-0295
DOI:10.1016/j.yrtph.2011.06.008

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