Synthesis of α-ketoamides via gold(I) carbene intermediates
α-Ketoamides have been found to be an important functional group in a broad spectrum of inhibitors such as the Corona virus and other viruses. Here we report an unprecedented gold-catalyzed 2-fold reaction of a bromoalkyne with anthranils. Hydrolysis of the initial product then directly leads to α-k...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 14, 2022
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| In: |
Organic letters
Year: 2022, Jahrgang: 24, Heft: 24, Pages: 4349-4353 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.2c01489 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.orglett.2c01489
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| Verfasserangaben: | Zuo Zuo Wu, Tapas Adak, Martin C. Dietl, Tao Wang, Chao Hu, Hongwei Shi, Petra Krämer, Matthias Rudolph, Frank Rominger, and A. Stephen K. Hashmi |
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| 520 | |a α-Ketoamides have been found to be an important functional group in a broad spectrum of inhibitors such as the Corona virus and other viruses. Here we report an unprecedented gold-catalyzed 2-fold reaction of a bromoalkyne with anthranils. Hydrolysis of the initial product then directly leads to α-ketoamides. Water addition to the intermediate α-iminoimidoyl halides delivered α-ketoamides from a broad range of bromoalkynes. | ||
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