Buchumschlag

Three-component synthesis of ynediones by a glyoxylation/Stephens-Castro coupling sequence

One step back, two steps forward! Starting from diverse heterocycles, the title reaction furnishes ynediones under very mild conditions in a direct and preparatively simple one-pot process. The key to avoiding decarbonylation is the CuI-catalyzed Stephens-Castro alkynylation rather than the usually...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Merkul, Eugen (VerfasserIn) , Dohe, Janis (VerfasserIn) , Gers, Charlotte (VerfasserIn) , Rominger, Frank (VerfasserIn) , Müller, Thomas J. J. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 February 2011
In: Angewandte Chemie. International edition
Year: 2011, Jahrgang: 50, Heft: 13, Pages: 2966-2969
ISSN:1521-3773
DOI:10.1002/anie.201007194
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/anie.201007194
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201007194
Volltext
Verfasserangaben:Eugen Merkul, Janis Dohe, Charlotte Gers, Frank Rominger, and Thomas J.J. Müller
Beschreibung
Zusammenfassung:One step back, two steps forward! Starting from diverse heterocycles, the title reaction furnishes ynediones under very mild conditions in a direct and preparatively simple one-pot process. The key to avoiding decarbonylation is the CuI-catalyzed Stephens-Castro alkynylation rather than the usually more efficient Sonogashira coupling. In addition, novel highly atom-economical four-component syntheses of various heterocycles can be achieved.
Beschreibung:Gesehen am 18.08.2022
Beschreibung:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.201007194

Ähnliche Einträge