Carboxyhemoglobin (CO-Hb) correlates with hemolysis and hospital mortality in extracorporeal membrane oxygenation: a retrospective registry
Background: Patients supported with extracorporeal membrane oxygenation (ECMO) may develop elevated carboxyhemoglobin (CO-Hb), a finding described in the context of hemolysis. Clinical relevance of elevated CO-Hb in ECMO is unclear. We therefore investigated the prognostic relevance of CO-Hb during...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
5 July 2022
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| In: |
Diagnostics
Year: 2022, Jahrgang: 12, Heft: 7, Pages: 1-11 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics12071642 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.3390/diagnostics12071642 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2075-4418/12/7/1642 
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| Verfasserangaben: | Xavier Bemtgen, Jonathan Rilinger, Manuel Holst, Felix Rottmann, Corinna N. Lang, Markus Jäckel, Viviane Zotzmann, Christoph Benk, Tobias Wengenmayer, Alexander Supady and Dawid L. Staudacher |
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| 245 | 1 | 0 | |a Carboxyhemoglobin (CO-Hb) correlates with hemolysis and hospital mortality in extracorporeal membrane oxygenation |b a retrospective registry |c Xavier Bemtgen, Jonathan Rilinger, Manuel Holst, Felix Rottmann, Corinna N. Lang, Markus Jäckel, Viviane Zotzmann, Christoph Benk, Tobias Wengenmayer, Alexander Supady and Dawid L. Staudacher |
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| 520 | |a Background: Patients supported with extracorporeal membrane oxygenation (ECMO) may develop elevated carboxyhemoglobin (CO-Hb), a finding described in the context of hemolysis. Clinical relevance of elevated CO-Hb in ECMO is unclear. We therefore investigated the prognostic relevance of CO-Hb during ECMO support. Methods: Data derives from a retrospective single-center registry study. All ECMO patients in a medical ICU from October 2010 through December 2019 were considered. Peak arterial CO-Hb value during ECMO support and median CO-Hb values determined by point-of-care testing for distinct time intervals were determined. Groups were divided by CO-Hb (<2% or ≥2%). The primary endpoint was hospital survival. Results: A total of 729 patients with 59,694 CO-Hb values met the inclusion criteria. Median age (IQR) was 59 (48-68) years, 221/729 (30.3%) were female, and 278/729 (38.1%) survived until hospital discharge. Initial ECMO configuration was veno-arterial in 431/729 (59.1%) patients and veno-venous in 298/729 (40.9%) patients. Markers for hemolysis (lactate dehydrogenase, bilirubin, hemolysis index, and haptoglobin) all correlated significantly with higher CO-Hb (p < 0.001, respectively). Hospital survival was significantly higher in patients with CO-Hb < 2% compared to CO-Hb ≥ 2%, evaluating time periods 24-48 h (48.6% vs. 35.2%, p = 0.003), 48-72 h (51.5% vs. 36.8%, p = 0.003), or >72 h (56.9% vs. 31.1%, p < 0.001) after ECMO cannulation. Peak CO-Hb was independently associated with lower hospital survival after adjustment for confounders. Conclusions: In ECMO, CO-Hb correlates with hemolysis and hospital survival. If high CO-Hb measured should trigger a therapeutic intervention in order to reduce hemolysis has to be investigated in prospective trials. | ||
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