Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially regulated promoters. In the heart, total PGC-1α deficiency knockout lead...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 July 2022
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| In: |
BMC biology
Year: 2022, Volume: 20, Pages: 1-20 |
| ISSN: | 1741-7007 |
| DOI: | 10.1186/s12915-022-01360-w |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12915-022-01360-w
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| Author Notes: | Daniel Oehler, André Spychala, Axel Gödecke, Alexander Lang, Norbert Gerdes, Jorge Ruas, Malte Kelm, Julia Szendroedi and Ralf Westenfeld |
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| 520 | |a Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) acts as a transcriptional coactivator and regulates mitochondrial function. Various isoforms are generated by alternative splicing and differentially regulated promoters. In the heart, total PGC-1α deficiency knockout leads to dilatative cardiomyopathy, but knowledge on the complexity of cardiac isoform expression of PGC-1α remains sparse. Thus, this study aims to generate a reliable dataset on cardiac isoform expression pattern by long-read mRNA sequencing, followed by investigation of differential regulation of PGC-1α isoforms under metabolic and ischemic stress, using high-fat-high-sucrose-diet-induced obesity and a murine model of myocardial infarction. | ||
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