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Specific targeting of antiapoptotic Bcl-2 proteins as a radiosensitizing approach in solid tumors

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Avoidance of therapy-induced apoptosis is a hallmark of acquired resistance towards radiotherapy. Thus, breaking resistance still challenges modern cancer therapy. The Bcl-2 protein family is known for its regulatory role in apoptosis signaling, making Bcl-2, Mcl-1 and Bcl-xL promising targets. This...

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Main Authors: Sobol, Benjamin (Author) , Azzam Nieto, Osama (Author) , Eberlein, Emily Lara (Author) , Scherr, Anna-Lena (Author) , Ismail, Lars (Author) , Keßler, Annika (Author) , Nader, Luisa (Author) , Schwab, Maximilian (Author) , Hoffmeister-Wittmann, Paula (Author) , Schmitt, Nathalie (Author) , Jäger, Dirk (Author) , Welte, Stefan Ezechiel (Author) , Seidensaal, Katharina (Author) , Christopoulos, Petros (Author) , Heilig, Christoph E. (Author) , Kriegsmann, Katharina (Author) , Fröhling, Stefan (Author) , Kriegsmann, Mark (Author) , Heß, Jochen (Author) , Köhler, Bruno Christian (Author)
Format: Article (Journal)
Language:English
Published: 16 July 2022
In: International journal of molecular sciences
Year: 2022, Volume: 23, Issue: 14, Pages: 1-13
ISSN:1422-0067
DOI:10.3390/ijms23147850
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms23147850
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/23/14/7850
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Author Notes:Benjamin Sobol, Osama Azzam Nieto, Emily Lara Eberlein, Anna-Lena Scherr, Lars Ismail, Annika Kessler, Luisa Nader, Maximilian Schwab, Paula Hoffmeister, Nathalie Schmitt, Dirk Jäger, Stefan Welte, Katharina Seidensaal, Petros Christopoulos, Christoph Heilig, Katharina Kriegsmann, Stefan Fröhling, Mark Kriegsmann, Jochen Hess and Bruno Christian Köhler
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TREM2 is associated with advanced stages and inferior prognosis in oral squamous cell carcinoma by Struckmeier, Ann-Kristin (Author) , Radermacher, Anne (Author) , Fehrenz, Michael (Author) , Alansary, Dalia (Author) , Wartenberg, Philipp (Author) , Wagner, Mathias (Author) , Scheller, Anja (Author) , Heß, Jochen (Author) , Moratin, Julius (Author) , Freudlsperger, Christian (Author) , Hoffmann, Jürgen (Author) , Thurner, Lorenz (Author) , Roemer, Klaus (Author) , Freier, Kolja (Author) , Horn, Dominik (Author) ,


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Efficacy of immune checkpoint inhibitors alone or in combination with chemotherapy in NSCLC harboring ERBB2 mutations by Saalfeld, Felix (Author) , Wenzel, Carina (Author) , Christopoulos, Petros (Author) , Merkelbach-Bruse, Sabine (Author) , Reissig, Timm M. (Author) , Laßmann, Silke (Author) , Thiel, Sebastian (Author) , Stratmann, Jan A. (Author) , Marienfeld, Ralf (Author) , Berger, Johannes (Author) , Desuki, Alexander (Author) , Velthaus, Janna-Lisa (Author) , Kauffmann-Guerrero, Diego (Author) , Stenzinger, Albrecht (Author) , Michels, Sebastian (Author) , Herold, Thomas (Author) , Kramer, Michael (Author) , Herold, Sylvia (Author) , Tufman, Amanda (Author) , Loges, Sonja (Author) , Alt, Jürgen (Author) , Joosten, Maria (Author) , Schmidtke-Schrezenmeier, Gerlinde (Author) , Sebastian, Martin (Author) , Stephan-Falkenau, Susann (Author) , Waller, Cornelius F. (Author) , Wiesweg, Marcel (Author) , Wolf, Jürgen (Author) , Thomas, Michael (Author) , Aust, Daniela E. (Author) , Wermke, Martin (Author) ,


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HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis by Albrecht, Thomas (Author) , Rössler, Stephanie (Author) , Braun, Jana D. (Author) , Mehrabi, Arianeb (Author) , Pathil-Warth, Anita (Author) , Mechtersheimer, Gunhild (Author) , Renner, Marcus (Author) , Rupp, Christian (Author) , Weiss, Karl Heinz (Author) , Busch, Elena (Author) , Köhler, Bruno Christian (Author) , Springfeld, Christoph (Author) , Schirmacher, Peter (Author) , Goeppert, Benjamin (Author) ,


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