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AKTing on XPO1 inhibition in AML

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Inhibition of XPO1-mediated nuclear export by selinexor represents a promising therapeutic strategy in acute myeloid leukemia. Because XPO1 is not specific for tumor-suppressive proteins, selinexor may also activate pro-oncogenic processes. A study now shows that inhibition of selinexor-induced, pur...

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Main Authors: Göllner, Stefanie (Author) , Müller-Tidow, Carsten (Author)
Format: Article (Journal)
Language:English
Published: 26 July 2022
In: Nature cancer
Year: 2022, Volume: 3, Issue: 7, Pages: 787-789
ISSN:2662-1347
DOI:10.1038/s43018-022-00395-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s43018-022-00395-w
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s43018-022-00395-w
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Author Notes:Stefanie Göllner and Carsten Müller-Tidow
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Five-year follow-up of a phase I trial of donor-derived modified immune cell infusion in kidney transplantation by Schaier, Matthias (Author) , Morath, Christian (Author) , Wang, Lei (Author) , Kleist, Christian (Author) , Opelz, Gerhard (Author) , Tran, Thuong Hien (Author) , Scherer, Sabine (Author) , Pham, Lien (Author) , Ekpoom, Naruemol (Author) , Süsal, Caner (Author) , Ponath, Gerald (Author) , Kälble, Florian (Author) , Speer, Claudius (Author) , Benning, Louise (Author) , Nußhag, Christian (Author) , Mahler, Christoph (Author) , Silva, Luiza Pego da (Author) , Sommerer, Claudia (Author) , Hückelhoven-Krauss, Angela (Author) , Czock, David (Author) , Mehrabi, Arianeb (Author) , Schwab, Constantin (Author) , Waldherr, Rüdiger (Author) , Schnitzler, Paul (Author) , Merle, Uta (Author) , Schwenger, Vedat (Author) , Krautter, Markus (Author) , Kemmner, Stephan Gerhard (Author) , Fischereder, Michael (Author) , Stangl, Manfred (Author) , Hauser, Ingeborg A. (Author) , Kälsch, Anna-Isabelle (Author) , Krämer, Bernhard (Author) , Böhmig, Georg A. (Author) , Müller-Tidow, Carsten (Author) , Reiser, Jochen (Author) , Zeier, Martin (Author) , Schmitt, Michael (Author) , Terness, Peter (Author) , Schmitt, Anita (Author) , Daniel, Volker (Author) ,


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