Buchumschlag

miR-29c increases protein synthesis in skeletal muscle independently of AKT/mTOR

microRNAs negatively regulate gene expression by blocking translation or increasing mRNA degradation. In skeletal muscle, these molecules play important roles in adaptive responses, and ongoing investigations are necessary to understand the fine-tune regulation of skeletal muscle mass. Herein we sho...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Alves, Paula (VerfasserIn) , Cruz, André (VerfasserIn) , Silva, William J. (VerfasserIn) , Labeit, Siegfried (VerfasserIn) , Moriscot, Anselmo Sigari (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 June 2022
In: International journal of molecular sciences
Year: 2022, Jahrgang: 23, Heft: 13, Pages: 1-11
ISSN:1422-0067
DOI:10.3390/ijms23137198
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms23137198
Volltext
Verfasserangaben:Paula Ketilly Nascimento Alves, André Cruz, William J. Silva, Siegfried Labeit and Anselmo Sigari Moriscot

MARC

LEADER 00000caa a2200000 c 4500
001 181475525X
003 DE-627
005 20230118152910.0
007 cr uuu---uuuuu
008 220819s2022 xx |||||o 00| ||eng c
024 7 |a 10.3390/ijms23137198  |2 doi 
035 |a (DE-627)181475525X 
035 |a (DE-599)KXP181475525X 
035 |a (OCoLC)1361706424 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Alves, Paula  |e VerfasserIn  |0 (DE-588)1265798524  |0 (DE-627)1814756175  |4 aut 
245 1 0 |a miR-29c increases protein synthesis in skeletal muscle independently of AKT/mTOR  |c Paula Ketilly Nascimento Alves, André Cruz, William J. Silva, Siegfried Labeit and Anselmo Sigari Moriscot 
264 1 |c 28 June 2022 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 19.08.2022 
520 |a microRNAs negatively regulate gene expression by blocking translation or increasing mRNA degradation. In skeletal muscle, these molecules play important roles in adaptive responses, and ongoing investigations are necessary to understand the fine-tune regulation of skeletal muscle mass. Herein we showed that skeletal muscle overexpression of miR-29c increased fiber size and force at 7 and 30 days after electrotransfer. At both time points, AKT/mTOR pathway components were downregulated, and, surprisingly, overall protein synthesis was strongly elevated at day 7, which normalized by day 30 after pCMVmiR-29c electrotransfer. These results indicate that miR-29c expression induces skeletal muscle hypertrophy and gain of function, which involves increased overall protein synthesis in spite of the deactivation of the AKT/mTOR pathway. 
650 4 |a AKT 
650 4 |a mice 
650 4 |a MicroRNAs 
650 4 |a miR-29c 
650 4 |a mTOR 
650 4 |a Muscle, Skeletal 
650 4 |a protein synthesis 
650 4 |a Proto-Oncogene Proteins c-akt 
650 4 |a skeletal muscle 
650 4 |a TOR Serine-Threonine Kinases 
700 1 |a Cruz, André  |e VerfasserIn  |4 aut 
700 1 |a Silva, William J.  |e VerfasserIn  |4 aut 
700 1 |a Labeit, Siegfried  |d 1960-  |e VerfasserIn  |0 (DE-588)1033566837  |0 (DE-627)741562375  |0 (DE-576)381187314  |4 aut 
700 1 |a Moriscot, Anselmo Sigari  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t International journal of molecular sciences  |d Basel : Molecular Diversity Preservation International, 2000  |g 23(2022), 13, Artikel-ID 7198, Seite 1-11  |h Online-Ressource  |w (DE-627)316340715  |w (DE-600)2019364-6  |w (DE-576)281194653  |x 1422-0067  |7 nnas  |a miR-29c increases protein synthesis in skeletal muscle independently of AKT/mTOR 
773 1 8 |g volume:23  |g year:2022  |g number:13  |g elocationid:7198  |g pages:1-11  |g extent:11  |a miR-29c increases protein synthesis in skeletal muscle independently of AKT/mTOR 
856 4 0 |u https://doi.org/10.3390/ijms23137198  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20220819 
993 |a Article 
994 |a 2022 
998 |g 1033566837  |a Labeit, Siegfried  |m 1033566837:Labeit, Siegfried  |d 60000  |d 61600  |e 60000PL1033566837  |e 61600PL1033566837  |k 0/60000/  |k 1/60000/61600/  |p 4 
999 |a KXP-PPN181475525X  |e 4181109267 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title":"miR-29c increases protein synthesis in skeletal muscle independently of AKT/mTOR","title_sort":"miR-29c increases protein synthesis in skeletal muscle independently of AKT/mTOR"}],"person":[{"family":"Alves","given":"Paula","role":"aut","display":"Alves, Paula"},{"display":"Cruz, André","given":"André","role":"aut","family":"Cruz"},{"family":"Silva","display":"Silva, William J.","given":"William J.","role":"aut"},{"display":"Labeit, Siegfried","role":"aut","given":"Siegfried","family":"Labeit"},{"family":"Moriscot","role":"aut","given":"Anselmo Sigari","display":"Moriscot, Anselmo Sigari"}],"name":{"displayForm":["Paula Ketilly Nascimento Alves, André Cruz, William J. Silva, Siegfried Labeit and Anselmo Sigari Moriscot"]},"relHost":[{"part":{"volume":"23","text":"23(2022), 13, Artikel-ID 7198, Seite 1-11","year":"2022","issue":"13","extent":"11","pages":"1-11"},"language":["eng"],"title":[{"title":"International journal of molecular sciences","title_sort":"International journal of molecular sciences"}],"pubHistory":["1.2000 -"],"recId":"316340715","origin":[{"publisherPlace":"Basel","dateIssuedDisp":"2000-","publisher":"Molecular Diversity Preservation International","dateIssuedKey":"2000"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"IJMS"}],"note":["Gesehen am 17.09.20"],"id":{"eki":["316340715"],"issn":["1422-0067","1661-6596"],"zdb":["2019364-6"]},"disp":"miR-29c increases protein synthesis in skeletal muscle independently of AKT/mTORInternational journal of molecular sciences","physDesc":[{"extent":"Online-Ressource"}]}],"note":["Gesehen am 19.08.2022"],"physDesc":[{"extent":"11 S."}],"id":{"doi":["10.3390/ijms23137198"],"eki":["181475525X"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"28 June 2022","dateIssuedKey":"2022"}],"recId":"181475525X"} 
SRT |a ALVESPAULAMIR29CINCR2820 

Ähnliche Einträge