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The role of polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 genes in non-surgical periodontal therapy

Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent...

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Main Authors: Walther, Kay-Arne (Author) , Gonzales, José Roberto (Author) , Gröger, Sabine (Author) , Ehmke, Benjamin (Author) , Kaner, Dogan (Author) , Lorenz, Katrin (Author) , Eickholz, Peter (Author) , Kocher, Thomas (Author) , Kim, Ti-Sun (Author) , Schlagenhauf, Ulrich (Author) , Koch, Raphael (Author) , Meyle, Jörg (Author)
Format: Article (Journal)
Language:English
Published: 30 June 2022
In: International journal of molecular sciences
Year: 2022, Volume: 23, Issue: 13, Pages: 1-18
ISSN:1422-0067
DOI:10.3390/ijms23137266
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms23137266
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Author Notes:Kay-Arne Walther, José Roberto Gonzales, Sabine Gröger, Benjamin Ehmke, Dogan Kaner, Katrin Lorenz, Peter Eickholz, Thomas Kocher, Ti-Sun Kim, Ulrich Schlagenhauf, Raphael Koch and Jörg Meyle
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Summary:Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov NCT00707369=ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression.
Item Description:Gesehen am 23.08.2022
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms23137266

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