The role of polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 genes in non-surgical periodontal therapy
Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 June 2022
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| In: |
International journal of molecular sciences
Year: 2022, Volume: 23, Issue: 13, Pages: 1-18 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms23137266 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms23137266
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| Author Notes: | Kay-Arne Walther, José Roberto Gonzales, Sabine Gröger, Benjamin Ehmke, Dogan Kaner, Katrin Lorenz, Peter Eickholz, Thomas Kocher, Ti-Sun Kim, Ulrich Schlagenhauf, Raphael Koch and Jörg Meyle |
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| 245 | 1 | 4 | |a The role of polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 genes in non-surgical periodontal therapy |c Kay-Arne Walther, José Roberto Gonzales, Sabine Gröger, Benjamin Ehmke, Dogan Kaner, Katrin Lorenz, Peter Eickholz, Thomas Kocher, Ti-Sun Kim, Ulrich Schlagenhauf, Raphael Koch and Jörg Meyle |
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| 520 | |a Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov NCT00707369=ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression. | ||
| 650 | 4 | |a Anti-Bacterial Agents | |
| 650 | 4 | |a antibiotics | |
| 650 | 4 | |a Cyclooxygenase 2 | |
| 650 | 4 | |a Cyclooxygenase-2 | |
| 650 | 4 | |a GATA-3 | |
| 650 | 4 | |a GATA3 Transcription Factor | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Interleukin-1 | |
| 650 | 4 | |a Interleukin-4 | |
| 650 | 4 | |a periodontal therapy | |
| 650 | 4 | |a periodontitis | |
| 650 | 4 | |a Periodontitis | |
| 650 | 4 | |a Polymorphism, Single Nucleotide | |
| 650 | 4 | |a polymorphisms | |
| 650 | 4 | |a risk factor | |
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