Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder
Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is strongly associated with Epstein-Barr virus (EBV). We analysed intrathecal production of EBV viral capsid antigen (VCA) immunoglobulin (Ig)G and IgA and Epstein-Barr nuclear antigen-1 (EBNA-1) IgG in nine pati...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2 June 2022
|
| In: |
Journal of neuroimmunology
Year: 2022, Volume: 369, Pages: 1-9 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2022.577902 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneuroim.2022.577902 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165572822000972 
|
| Author Notes: | Carolin Otto, Helena Radbruch, Diana Wilken, Tatjana Lietzow, Katja Steinhagen, Evelin Grage-Griebenow, Ann-Christin von Brünneck, Sven Jarius, Jörg Hofmann, Florence Pache, Klemens Ruprecht |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1815180862 | ||
| 003 | DE-627 | ||
| 005 | 20230427000310.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220825s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jneuroim.2022.577902 |2 doi | |
| 035 | |a (DE-627)1815180862 | ||
| 035 | |a (DE-599)KXP1815180862 | ||
| 035 | |a (OCoLC)1361697105 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Otto, Carolin |d 1986- |e VerfasserIn |0 (DE-588)1042803471 |0 (DE-627)769748007 |0 (DE-576)394242157 |4 aut | |
| 245 | 1 | 0 | |a Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder |c Carolin Otto, Helena Radbruch, Diana Wilken, Tatjana Lietzow, Katja Steinhagen, Evelin Grage-Griebenow, Ann-Christin von Brünneck, Sven Jarius, Jörg Hofmann, Florence Pache, Klemens Ruprecht |
| 264 | 1 | |c 2 June 2022 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.08.2022 | ||
| 520 | |a Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is strongly associated with Epstein-Barr virus (EBV). We analysed intrathecal production of EBV viral capsid antigen (VCA) immunoglobulin (Ig)G and IgA and Epstein-Barr nuclear antigen-1 (EBNA-1) IgG in nine patients with PNCS-PTLD and 20 patients with non-inflammatory neurological diseases (NINDs). Intrathecally produced VCA-IgG was detected in 7/9 (78%), VCA-IgA in 6/9 (67%) and EBNA-1-IgG in 2/9 (22%) patients with PCNS-PTLD, but not in NINDs. This exploratory study suggests that intrathecal EBV antibody production might be frequent in PCNS-PTLD. Detecting intrathecally produced VCA-IgG and VCA-IgA could thus potentially be helpful for diagnosing PCNS-PTLD. | ||
| 650 | 4 | |a Antibody index | |
| 650 | 4 | |a Central nervous system | |
| 650 | 4 | |a Cerebrospinal fluid | |
| 650 | 4 | |a Epstein-Barr virus, viral capsid antigen | |
| 650 | 4 | |a Post-transplant lymphoproliferative disorder | |
| 700 | 1 | |a Radbruch, Helena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wilken, Diana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lietzow, Tatjana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steinhagen, Katja |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grage-Griebenow, Evelin |e VerfasserIn |4 aut | |
| 700 | 1 | |a von Brünneck, Ann-Christin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jarius, Sven |e VerfasserIn |0 (DE-588)1054615918 |0 (DE-627)791654818 |0 (DE-576)410367478 |4 aut | |
| 700 | 1 | |a Hofmann, Jörg |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pache, Florence |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ruprecht, Klemens |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuroimmunology |d Amsterdam [u.a.] : Elsevier Science, 1981 |g 369(2022) vom: 15. Aug., Artikel-ID 577902, Seite 1-9 |h Online-Ressource |w (DE-627)306659778 |w (DE-600)1500497-1 |w (DE-576)081986408 |x 1872-8421 |7 nnas |a Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder |
| 773 | 1 | 8 | |g volume:369 |g year:2022 |g day:15 |g month:08 |g elocationid:577902 |g pages:1-9 |g extent:9 |a Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jneuroim.2022.577902 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0165572822000972 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220825 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1054615918 |a Jarius, Sven |m 1054615918:Jarius, Sven |d 910000 |d 911100 |e 910000PJ1054615918 |e 911100PJ1054615918 |k 0/910000/ |k 1/910000/911100/ |p 8 | ||
| 999 | |a KXP-PPN1815180862 |e 4182672186 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"eki":["1815180862"],"doi":["10.1016/j.jneuroim.2022.577902"]},"physDesc":[{"extent":"9 S."}],"note":["Gesehen am 25.08.2022"],"recId":"1815180862","person":[{"display":"Otto, Carolin","given":"Carolin","family":"Otto","role":"aut","roleDisplay":"VerfasserIn"},{"display":"Radbruch, Helena","given":"Helena","family":"Radbruch","role":"aut","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wilken, Diana","family":"Wilken","given":"Diana"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Lietzow","given":"Tatjana","display":"Lietzow, Tatjana"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Steinhagen, Katja","given":"Katja","family":"Steinhagen"},{"display":"Grage-Griebenow, Evelin","given":"Evelin","family":"Grage-Griebenow","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","family":"von Brünneck","given":"Ann-Christin","display":"von Brünneck, Ann-Christin"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Jarius","given":"Sven","display":"Jarius, Sven"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Hofmann","given":"Jörg","display":"Hofmann, Jörg"},{"family":"Pache","given":"Florence","display":"Pache, Florence","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ruprecht, Klemens","given":"Klemens","family":"Ruprecht"}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["1500497-1"],"eki":["306659778"],"issn":["1872-8421"]},"disp":"Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorderJournal of neuroimmunology","recId":"306659778","part":{"volume":"369","extent":"9","text":"369(2022) vom: 15. Aug., Artikel-ID 577902, Seite 1-9","year":"2022","pages":"1-9"},"note":["Gesehen am 19.02.20","Ungezählte Beil.: Supplement"],"title":[{"title_sort":"Journal of neuroimmunology","subtitle":"official journal of the International Society for Neuroimmunology","title":"Journal of neuroimmunology"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"pubHistory":["1.1981 -"],"origin":[{"dateIssuedDisp":"1981-","publisher":"Elsevier Science","dateIssuedKey":"1981","publisherPlace":"Amsterdam [u.a.]"}]}],"name":{"displayForm":["Carolin Otto, Helena Radbruch, Diana Wilken, Tatjana Lietzow, Katja Steinhagen, Evelin Grage-Griebenow, Ann-Christin von Brünneck, Sven Jarius, Jörg Hofmann, Florence Pache, Klemens Ruprecht"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"2 June 2022","dateIssuedKey":"2022"}],"language":["eng"],"title":[{"title_sort":"Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder","title":"Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder"}]} | ||
| SRT | |a OTTOCAROLIFREQUENTIN2202 | ||