Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex
The basal nucleus of Meynert (NBM) subserves critically important functions in attention, arousal and cognition via its profound modulation of neocortical activity and is emerging as a key target in Alzheimer’s and Parkinson’s dementias. Despite the crucial role of neocortical domains in pain percep...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 August 2022
|
| In: |
Nature Communications
Year: 2022, Volume: 13, Pages: 1-18 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-022-32558-9 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41467-022-32558-9 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-022-32558-9 
|
| Author Notes: | Manfred J. Oswald, Yechao Han, Han Li, Samuel Marashli, Deniz Nouri Oglo, Bhavya Ojha, Paul V. Naser, Zheng Gan & Rohini Kuner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1815292598 | ||
| 003 | DE-627 | ||
| 005 | 20230427000345.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220829s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-022-32558-9 |2 doi | |
| 035 | |a (DE-627)1815292598 | ||
| 035 | |a (DE-599)KXP1815292598 | ||
| 035 | |a (OCoLC)1361697041 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Oswald, Manfred |e VerfasserIn |0 (DE-588)1236371429 |0 (DE-627)1761731769 |4 aut | |
| 245 | 1 | 0 | |a Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex |c Manfred J. Oswald, Yechao Han, Han Li, Samuel Marashli, Deniz Nouri Oglo, Bhavya Ojha, Paul V. Naser, Zheng Gan & Rohini Kuner |
| 264 | 1 | |c 25 August 2022 | |
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.08.2022 | ||
| 520 | |a The basal nucleus of Meynert (NBM) subserves critically important functions in attention, arousal and cognition via its profound modulation of neocortical activity and is emerging as a key target in Alzheimer’s and Parkinson’s dementias. Despite the crucial role of neocortical domains in pain perception, however, the NBM has not been studied in models of chronic pain. Here, using in vivo tetrode recordings in behaving mice, we report that beta and gamma oscillatory activity is evoked in the NBM by noxious stimuli and is facilitated at peak inflammatory pain-like behavior. Optogenetic and chemogenetic cell-specific, reversible manipulations of NBM cholinergic-GABAergic neurons reveal their role in endogenous control of nociceptive hypersensitivity, which are manifest via projections to the prelimbic cortex, resulting in layer 5-mediated antinociception. Our data unravel the importance of the NBM in top-down control of neocortical processing of pain-like behavior. | ||
| 650 | 4 | |a Chronic pain | |
| 650 | 4 | |a Neural circuits | |
| 700 | 1 | |a Han, Yechao |e VerfasserIn |0 (DE-588)1262906326 |0 (DE-627)1810814928 |4 aut | |
| 700 | 1 | |a Li, Han |e VerfasserIn |0 (DE-588)123637021X |0 (DE-627)1761730665 |4 aut | |
| 700 | 1 | |a Marashli, Samuel |e VerfasserIn |0 (DE-588)1262907764 |0 (DE-627)1810817765 |4 aut | |
| 700 | 1 | |a Nouri Oglou, Deniz |e VerfasserIn |0 (DE-588)1262907977 |0 (DE-627)1810818346 |4 aut | |
| 700 | 1 | |a Ojha, Bhavya |e VerfasserIn |0 (DE-588)1262908116 |0 (DE-627)1810818702 |4 aut | |
| 700 | 1 | |a Naser, Paul |d 1995- |e VerfasserIn |0 (DE-588)1167719875 |0 (DE-627)1031239901 |0 (DE-576)511233426 |4 aut | |
| 700 | 1 | |a Gan, Zheng |d 1984- |e VerfasserIn |0 (DE-588)1236369114 |0 (DE-627)176172942X |4 aut | |
| 700 | 1 | |a Kuner, Rohini |d 1970- |e VerfasserIn |0 (DE-588)1033243426 |0 (DE-627)741191393 |0 (DE-576)250796732 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 13(2022), Artikel-ID 5014, Seite 1-18 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex |
| 773 | 1 | 8 | |g volume:13 |g year:2022 |g elocationid:5014 |g pages:1-18 |g extent:18 |a Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-022-32558-9 |x Resolving-System |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-022-32558-9 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220829 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1033243426 |a Kuner, Rohini |m 1033243426:Kuner, Rohini |d 50000 |d 54600 |e 50000PK1033243426 |e 54600PK1033243426 |k 0/50000/ |k 1/50000/54600/ |p 9 |y j | ||
| 998 | |g 1236369114 |a Gan, Zheng |m 1236369114:Gan, Zheng |d 50000 |d 54600 |e 50000PG1236369114 |e 54600PG1236369114 |k 0/50000/ |k 1/50000/54600/ |p 8 | ||
| 998 | |g 1167719875 |a Naser, Paul |m 1167719875:Naser, Paul |d 910000 |d 911200 |e 910000PN1167719875 |e 911200PN1167719875 |k 0/910000/ |k 1/910000/911200/ |p 7 | ||
| 998 | |g 1262908116 |a Ojha, Bhavya |m 1262908116:Ojha, Bhavya |p 6 | ||
| 998 | |g 1262907977 |a Nouri Oglou, Deniz |m 1262907977:Nouri Oglou, Deniz |p 5 | ||
| 998 | |g 1262907764 |a Marashli, Samuel |m 1262907764:Marashli, Samuel |d 140000 |e 140000PM1262907764 |k 0/140000/ |p 4 | ||
| 998 | |g 123637021X |a Li, Han |m 123637021X:Li, Han |p 3 | ||
| 998 | |g 1262906326 |a Han, Yechao |m 1262906326:Han, Yechao |d 50000 |d 53100 |e 50000PH1262906326 |e 53100PH1262906326 |k 0/50000/ |k 1/50000/53100/ |p 2 | ||
| 998 | |g 1236371429 |a Oswald, Manfred |m 1236371429:Oswald, Manfred |d 50000 |d 54600 |e 50000PO1236371429 |e 54600PO1236371429 |k 0/50000/ |k 1/50000/54600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1815292598 |e 4183220793 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 13.06.24"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2553671-0"],"eki":["626457688"],"issn":["2041-1723"]},"part":{"year":"2022","volume":"13","extent":"18","text":"13(2022), Artikel-ID 5014, Seite 1-18","pages":"1-18"},"pubHistory":["2010-"],"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}],"origin":[{"publisherPlace":"[London] ; [London]","dateIssuedDisp":"[2010]-","publisher":"Springer Nature ; Nature Publishing Group UK"}],"disp":"Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortexNature Communications","recId":"626457688","language":["eng"]}],"id":{"doi":["10.1038/s41467-022-32558-9"],"eki":["1815292598"]},"physDesc":[{"extent":"18 S."}],"note":["Gesehen am 29.08.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Manfred J. Oswald, Yechao Han, Han Li, Samuel Marashli, Deniz Nouri Oglo, Bhavya Ojha, Paul V. Naser, Zheng Gan & Rohini Kuner"]},"person":[{"roleDisplay":"VerfasserIn","role":"aut","given":"Manfred","display":"Oswald, Manfred","family":"Oswald"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Yechao","display":"Han, Yechao","family":"Han"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Han","display":"Li, Han","family":"Li"},{"roleDisplay":"VerfasserIn","family":"Marashli","display":"Marashli, Samuel","given":"Samuel","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Nouri Oglou, Deniz","family":"Nouri Oglou","role":"aut","given":"Deniz"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Bhavya","display":"Ojha, Bhavya","family":"Ojha"},{"role":"aut","given":"Paul","display":"Naser, Paul","family":"Naser","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","given":"Zheng","role":"aut","family":"Gan","display":"Gan, Zheng"},{"family":"Kuner","display":"Kuner, Rohini","role":"aut","given":"Rohini","roleDisplay":"VerfasserIn"}],"language":["eng"],"recId":"1815292598","origin":[{"dateIssuedDisp":"25 August 2022","dateIssuedKey":"2022"}],"title":[{"title_sort":"Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex","title":"Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex"}]} | ||
| SRT | |a OSWALDMANFCHOLINERGI2520 | ||