Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease

The ring-forming AAA+ hexamer ClpC1 associates with the peptidase ClpP1P2 to form a central ATP-driven protease in Mycobacterium tuberculosis (Mtb). ClpC1 is essential for Mtb viability and has been identified as the target of antibacterial peptides like CyclomarinA (CymA) that exhibit strong toxici...

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Main Authors:	Taylor, Gabrielle (Author) , Frommherz, Yannick (Author) , Katikaridis, Panagiotis (Author) , Layer, Dominik Christian (Author) , Sinning, Irmgard (Author) , Carroni, Marta (Author) , Weber-Ban, Eilika (Author) , Mogk, Axel (Author)
Format:	Article (Journal)
Language:	English
Published:	August 2022
In:	The journal of biological chemistry Year: 2022, Volume: 298, Issue: 8, Pages: 1-12
ISSN:	1083-351X
DOI:	10.1016/j.jbc.2022.102202
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jbc.2022.102202 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0021925822006445
Author Notes:	Gabrielle Taylor, Yannick Frommherz, Panagiotis Katikaridis, Dominik Layer, Irmgard Sinning, Marta Carroni, Eilika Weber-Ban, and Axel Mogk

The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis by Kharde, Satyavati (Author) , Calviño, Fabiola R. (Author) , Gumiero, Andrea (Author) , Wild, Klemens (Author) , Sinning, Irmgard (Author) ,

in: Nucleic acids research, 43 (2015), 14, Seite 7083-7095

Article (Journal) Online Resource

Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease

The structure of Rpf2-Rrs1 explains its role in ribosome biogenesis by Kharde, Satyavati (Author) , Calviño, Fabiola R. (Author) , Gumiero, Andrea (Author) , Wild, Klemens (Author) , Sinning, Irmgard (Author) ,

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