Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic?: a review of evidence and the technological landscape
Advances in discovery and validation of diagnostic, prognostic and treatment-monitoring transcriptomic signatures of tuberculosis (TB) disease could accelerate the goal to end TB. We conducted a review to evaluate whether mRNA transcriptomics technologies are sufficiently mature to develop accurate...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 July 2022
|
| In: |
EBioMedicine
Year: 2022, Volume: 82, Pages: 1-12 |
| ISSN: | 2352-3964 |
| DOI: | 10.1016/j.ebiom.2022.104174 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ebiom.2022.104174 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2352396422003553 
|
| Author Notes: | Yohhei Hamada, Adam Penn-Nicholson, Sriram Krishnan, Daniela Maria Cirillo, Alberto Matteelli, Romain Wyss, Claudia M. Denkinger, Molebogeng X. Rangaka, Morten Ruhwald, and Samuel G. Schumacher |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1815842164 | ||
| 003 | DE-627 | ||
| 005 | 20240417193409.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220906s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ebiom.2022.104174 |2 doi | |
| 035 | |a (DE-627)1815842164 | ||
| 035 | |a (DE-599)KXP1815842164 | ||
| 035 | |a (OCoLC)1361696784 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hamada, Yohhei |e VerfasserIn |4 aut | |
| 245 | 1 | 0 | |a Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? |b a review of evidence and the technological landscape |c Yohhei Hamada, Adam Penn-Nicholson, Sriram Krishnan, Daniela Maria Cirillo, Alberto Matteelli, Romain Wyss, Claudia M. Denkinger, Molebogeng X. Rangaka, Morten Ruhwald, and Samuel G. Schumacher |
| 264 | 1 | |c 15 July 2022 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.09.2022 | ||
| 520 | |a Advances in discovery and validation of diagnostic, prognostic and treatment-monitoring transcriptomic signatures of tuberculosis (TB) disease could accelerate the goal to end TB. We conducted a review to evaluate whether mRNA transcriptomics technologies are sufficiently mature to develop accurate next-generation TB diagnostic tests. Early studies tended to be limited in sample size, diversity of population groups, sample collection and processing methods, while recent prospective studies have addressed these limitations. Some of the existing signatures could be used for triage; however, high cost and complexity could limit their use. For a confirmatory test, setting an optimal cut-off to maintain specificity across populations and settings is a challenge. mRNA signatures have shown the potential to quantitatively monitor response to treatment. No prognostic signatures can accurately predict progression to active TB over 2 years while short term prediction is possible. The management strategy should be defined for individuals with positive prognostic tests. - Funding - Development of this manuscript was supported by funding received from the Stop TB Partnership and USAID for the New Diagnostics Working Group. The funders had no role in paper design, article selection and review, interpretation, or writing of the paper. | ||
| 650 | 4 | |a Fold change | |
| 650 | 4 | |a mRNA signature | |
| 650 | 4 | |a Point-of-care TB diagnostics | |
| 650 | 4 | |a Transcriptomics | |
| 700 | 1 | |a Penn-Nicholson, Adam |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krishnan, Sriram |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cirillo, Daniela Maria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Matteelli, Alberto |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wyss, Romain |e VerfasserIn |4 aut | |
| 700 | 1 | |a Denkinger, Claudia M. |d 1978- |e VerfasserIn |0 (DE-588)131597701 |0 (DE-627)511279469 |0 (DE-576)298613727 |4 aut | |
| 700 | 1 | |a Rangaka, Molebogeng X. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ruhwald, Morten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schumacher, Samuel G. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t EBioMedicine |d Amsterdam [u.a.] : Elsevier, 2014 |g 82(2022), Artikel-ID 104174, Seite 1-12 |h Online-Ressource |w (DE-627)802540074 |w (DE-600)2799017-5 |w (DE-576)416965725 |x 2352-3964 |7 nnas |a Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? a review of evidence and the technological landscape |
| 773 | 1 | 8 | |g volume:82 |g year:2022 |g elocationid:104174 |g pages:1-12 |g extent:12 |a Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? a review of evidence and the technological landscape |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ebiom.2022.104174 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S2352396422003553 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220906 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 131597701 |a Denkinger, Claudia M. |m 131597701:Denkinger, Claudia M. |d 910000 |d 911700 |d 50000 |e 910000PD131597701 |e 911700PD131597701 |e 50000PD131597701 |k 0/910000/ |k 1/910000/911700/ |k 0/50000/ |p 7 | ||
| 999 | |a KXP-PPN1815842164 |e 4184912400 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"12 S."}],"recId":"1815842164","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 06.09.2022"],"title":[{"title_sort":"Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic?","title":"Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic?","subtitle":"a review of evidence and the technological landscape"}],"origin":[{"dateIssuedDisp":"15 July 2022","dateIssuedKey":"2022"}],"person":[{"display":"Hamada, Yohhei","family":"Hamada","given":"Yohhei","role":"aut"},{"display":"Penn-Nicholson, Adam","family":"Penn-Nicholson","given":"Adam","role":"aut"},{"family":"Krishnan","role":"aut","given":"Sriram","display":"Krishnan, Sriram"},{"role":"aut","given":"Daniela Maria","family":"Cirillo","display":"Cirillo, Daniela Maria"},{"display":"Matteelli, Alberto","family":"Matteelli","given":"Alberto","role":"aut"},{"display":"Wyss, Romain","family":"Wyss","given":"Romain","role":"aut"},{"family":"Denkinger","role":"aut","given":"Claudia M.","display":"Denkinger, Claudia M."},{"display":"Rangaka, Molebogeng X.","family":"Rangaka","role":"aut","given":"Molebogeng X."},{"display":"Ruhwald, Morten","family":"Ruhwald","given":"Morten","role":"aut"},{"display":"Schumacher, Samuel G.","given":"Samuel G.","role":"aut","family":"Schumacher"}],"relHost":[{"disp":"Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? a review of evidence and the technological landscapeEBioMedicine","recId":"802540074","physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["2352-3964"],"eki":["802540074"],"zdb":["2799017-5"]},"part":{"pages":"1-12","year":"2022","text":"82(2022), Artikel-ID 104174, Seite 1-12","volume":"82","extent":"12"},"title":[{"title":"EBioMedicine","title_sort":"EBioMedicine"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 28.05.2020"],"origin":[{"dateIssuedDisp":"2014-","dateIssuedKey":"2014","publisherPlace":"Amsterdam [u.a.]","publisher":"Elsevier"}],"pubHistory":["Volume 1 (2014)-"]}],"id":{"doi":["10.1016/j.ebiom.2022.104174"],"eki":["1815842164"]},"name":{"displayForm":["Yohhei Hamada, Adam Penn-Nicholson, Sriram Krishnan, Daniela Maria Cirillo, Alberto Matteelli, Romain Wyss, Claudia M. Denkinger, Molebogeng X. Rangaka, Morten Ruhwald, and Samuel G. Schumacher"]}} | ||
| SRT | |a HAMADAYOHHAREMRNABAS1520 | ||