Design, synthesis and biological characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with anti-neuroblastoma activity
In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the activity of non-histone protein substrates. The knockdown of HDAC8 isozyme is associated with the inhibition of cell proliferation and apoptosis enhanceme...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 July 2022
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| In: |
International journal of molecular sciences
Year: 2022, Jahrgang: 23, Heft: 14, Pages: 1-31 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms23147535 |
| Online-Zugang: | Resolving-System, kostenfrei: https://doi.org/10.3390/ijms23147535 Resolving-System, kostenfrei: https://www.mdpi.com/1422-0067/23/14/7535 Resolving-System, kostenfrei: https://doi.org/10.25673/101632 
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| Verfasserangaben: | Salma Darwish, Ehab Ghazy, Tino Heimburg, Daniel Herp, Patrik Zeyen, Rabia Salem-Altintas, Johannes Ridinger, Dina Robaa, Karin Schmidtkunz, Frank Erdmann, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme and Wolfgang Sippl |
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The enzyme activity of histone deacetylase 8 is modulated by a redox-switch
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