Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats
3-Nitrobenzanthrone (3-NBA), a carcinogenic air pollutant, was investigated for its ability to induce cytochrome P450 (CYP) 1A1/2 and NAD(P)H:quinone oxidoreductase (NQO1) in liver, kidney and lung of rats treated by intra-tracheal instillation. The organs used were from a previous study performed t...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
|
| In: |
Mutation research. Genetic toxicology and environmental mutagenesis
Year: 2011, Jahrgang: 720, Heft: 1-2, Pages: 34-41 |
| ISSN: | 1388-2120 |
| DOI: | 10.1016/j.mrgentox.2010.12.003 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mrgentox.2010.12.003 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1383571810004109 
|
| Verfasserangaben: | Jana Mizerovská, Helena Dračínská, Eva Frei, Heinz H. Schmeiser, Volker M. Arlt, Marie Stiborová |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1815979437 | ||
| 003 | DE-627 | ||
| 005 | 20230710120925.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220907s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.mrgentox.2010.12.003 |2 doi | |
| 035 | |a (DE-627)1815979437 | ||
| 035 | |a (DE-599)KXP1815979437 | ||
| 035 | |a (OCoLC)1389792941 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Mizerovská, Jana |e VerfasserIn |0 (DE-588)1267507632 |0 (DE-627)1815980575 |4 aut | |
| 245 | 1 | 0 | |a Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats |c Jana Mizerovská, Helena Dračínská, Eva Frei, Heinz H. Schmeiser, Volker M. Arlt, Marie Stiborová |
| 264 | 1 | |c 2011 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 15 December 2010 | ||
| 500 | |a Gesehen am 07.09.2022 | ||
| 520 | |a 3-Nitrobenzanthrone (3-NBA), a carcinogenic air pollutant, was investigated for its ability to induce cytochrome P450 (CYP) 1A1/2 and NAD(P)H:quinone oxidoreductase (NQO1) in liver, kidney and lung of rats treated by intra-tracheal instillation. The organs used were from a previous study performed to determine the persistence of 3-NBA-derived DNA adducts in target and non-target tissues (Bieler et al., Carcinogenesis 28 (2007) 1117-1121, [22]). NQO1 is the enzyme reducing 3-NBA to N-hydroxy-3-aminobenzanthrone (N-OH-3-ABA) and CYP1A enzymes oxidize a human metabolite of 3-NBA, 3-aminobenzanthrone (3-ABA), to yield the same reactive intermediate. 3-NBA and 3-ABA are both activated to species forming DNA adducts by cytosols and/or microsomes isolated from rat lung, the target organ for 3-NBA carcinogenicity, and from liver and kidney. Each compound generated the same five DNA adducts detectable by 32P-postlabelling. When hepatic cytosols from rats treated with 0.2 or 2mg/kg body weight of 3-NBA were incubated with 3-NBA, DNA adduct formation was 3.2- and 8.6-fold higher, respectively, than in incubations with cytosols from control animals. Likewise, cytosols isolated from lungs and kidneys of rats exposed to 3-NBA more efficiently activated 3-NBA than those of control rats. This increase corresponded to an increase in protein levels and enzymatic activities of NQO1. Incubations of hepatic, pulmonary or renal microsomes of 3-NBA-treated rats with 3-ABA led to an 9.6-fold increase in DNA-adduct formation relative to controls. The highest induction in DNA-adduct levels was found in lung. The stimulation of DNA-adduct formation correlated with expression of CYP1A1/2 induced by the intra-tracheal instillation of 3-NBA. The results demonstrate that 3-NBA induces NQO1 and CYP1A1/2 in livers, lungs and kidneys of rats after intra-tracheal instillation, thereby enhancing its own genotoxic and carcinogenic potential. | ||
| 650 | 4 | |a 3-Nitrobenzanthrone | |
| 650 | 4 | |a Cytochrome P450 | |
| 650 | 4 | |a DNA adduct | |
| 650 | 4 | |a Enzyme induction | |
| 650 | 4 | |a NAD(P)H:quinone oxidoreductase | |
| 700 | 1 | |a Dračínská, Helena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Frei, Eva |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmeiser, Heinz |e VerfasserIn |0 (DE-588)1118395883 |0 (DE-627)871947374 |0 (DE-576)479451273 |4 aut | |
| 700 | 1 | |a Arlt, Volker M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stiborová, Marie |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Mutation research. Genetic toxicology and environmental mutagenesis |d Amsterdam [u.a.] : Elsevier Science, 1997 |g 720(2011), 1-2, Seite 34-41 |h Online-Ressource |w (DE-627)503327336 |w (DE-600)2210272-3 |w (DE-576)25588480X |x 1388-2120 |7 nnas |a Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats |
| 773 | 1 | 8 | |g volume:720 |g year:2011 |g number:1-2 |g pages:34-41 |g extent:8 |a Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.mrgentox.2010.12.003 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1383571810004109 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220907 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1118395883 |a Schmeiser, Heinz |m 1118395883:Schmeiser, Heinz |d 140000 |e 140000PS1118395883 |k 0/140000/ |p 4 | ||
| 999 | |a KXP-PPN1815979437 |e 4185320671 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"id":{"zdb":["2210272-3"],"eki":["503327336"],"issn":["1388-2120"]},"origin":[{"dateIssuedDisp":"1997-","publisher":"Elsevier Science","dateIssuedKey":"1997","publisherPlace":"Amsterdam [u.a.]"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Mutation research","title":"Mutation research","partname":"Genetic toxicology and environmental mutagenesis"}],"recId":"503327336","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in ratsMutation research. Genetic toxicology and environmental mutagenesis","note":["Gesehen am 20.02.20"],"titleAlt":[{"title":"Mutation research / Genetic toxicology and environmental mutagenesis"},{"title":"Genetic toxicology and environmental mutagenesis"}],"part":{"volume":"720","text":"720(2011), 1-2, Seite 34-41","extent":"8","year":"2011","pages":"34-41","issue":"1-2"},"pubHistory":["388.1997 -"]}],"physDesc":[{"extent":"8 S."}],"id":{"doi":["10.1016/j.mrgentox.2010.12.003"],"eki":["1815979437"]},"origin":[{"dateIssuedDisp":"2011","dateIssuedKey":"2011"}],"name":{"displayForm":["Jana Mizerovská, Helena Dračínská, Eva Frei, Heinz H. Schmeiser, Volker M. Arlt, Marie Stiborová"]},"recId":"1815979437","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Available online 15 December 2010","Gesehen am 07.09.2022"],"title":[{"title_sort":"Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats","title":"Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats"}],"person":[{"family":"Mizerovská","given":"Jana","display":"Mizerovská, Jana","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Dračínská","given":"Helena","roleDisplay":"VerfasserIn","display":"Dračínská, Helena","role":"aut"},{"family":"Frei","given":"Eva","roleDisplay":"VerfasserIn","display":"Frei, Eva","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Schmeiser, Heinz","role":"aut","family":"Schmeiser","given":"Heinz"},{"display":"Arlt, Volker M.","roleDisplay":"VerfasserIn","role":"aut","family":"Arlt","given":"Volker M."},{"role":"aut","display":"Stiborová, Marie","roleDisplay":"VerfasserIn","given":"Marie","family":"Stiborová"}]} | ||
| SRT | |a MIZEROVSKAINDUCTIONO2011 | ||