The multifunctional role of EMP3 in the regulation of membrane receptors associated with IDH-wild-type glioblastoma
Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models hav...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 May 2021
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| In: |
International journal of molecular sciences
Year: 2021, Jahrgang: 22, Heft: 10, Pages: 1-17 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22105261 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms22105261 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/22/10/5261 
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| Verfasserangaben: | Antoni Andreu Martija and Stefan Pusch |
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| 520 | |a Epithelial membrane protein 3 (EMP3) is a tetraspan membrane protein overexpressed in isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma (GBM). Several studies reported high EMP3 levels as a poor prognostic factor in GBM patients. Experimental findings based on glioma and non-glioma models have demonstrated the role of EMP3 in the regulation of several membrane proteins known to drive IDH-wt GBM. In this review, we summarize what is currently known about EMP3 biology. We discuss the regulatory effects that EMP3 exerts on a variety of oncogenic receptors and discuss how these mechanisms may relate to IDH-wt GBM. Lastly, we enumerate the open questions towards EMP3 function in IDH-wt GBM. | ||
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