Accurate classification of metastatic brain tumors using a novel microRNA‐based test
Identification of the tissue of origin of a brain metastatic tumor is vital to its management. Carcinoma of unknown primary (CUP) is common in oncology, representing 3%-5% of all invasive malignancies. We aimed to validate a recently developed microRNA‐based quantitative reverse transcriptase polyme...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 January 2011
|
| In: |
The oncologist
Year: 2011, Jahrgang: 16, Heft: 2, Pages: 165-174 |
| ISSN: | 1549-490X |
| DOI: | 10.1634/theoncologist.2010-0305 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1634/theoncologist.2010-0305
|
| Verfasserangaben: | Wolf C. Mueller, Yael Spector, Tina Bocker Edmonston, Brianna St. Cyr, Diana Jaeger, Ulrike Lass, Ranit Aharonov, Shai Rosenwald, Ayelet Chajut |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1816305448 | ||
| 003 | DE-627 | ||
| 005 | 20230710120205.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220908s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1634/theoncologist.2010-0305 |2 doi | |
| 035 | |a (DE-627)1816305448 | ||
| 035 | |a (DE-599)KXP1816305448 | ||
| 035 | |a (OCoLC)1389792111 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Müller, Wolf C. |d 1967- |e VerfasserIn |0 (DE-588)1075182743 |0 (DE-627)832987476 |0 (DE-576)34814184X |4 aut | |
| 245 | 1 | 0 | |a Accurate classification of metastatic brain tumors using a novel microRNA‐based test |c Wolf C. Mueller, Yael Spector, Tina Bocker Edmonston, Brianna St. Cyr, Diana Jaeger, Ulrike Lass, Ranit Aharonov, Shai Rosenwald, Ayelet Chajut |
| 264 | 1 | |c 27 January 2011 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.09.2022 | ||
| 520 | |a Identification of the tissue of origin of a brain metastatic tumor is vital to its management. Carcinoma of unknown primary (CUP) is common in oncology, representing 3%-5% of all invasive malignancies. We aimed to validate a recently developed microRNA‐based quantitative reverse transcriptase polymerase chain reaction (qRT‐PCR) test for identifying the tumor tissue of origin, first in a consecutive cohort of metastatic tumors of known origin and then in a cohort of CUP cases resected from the central nervous system (CNS).One hundred two resected CNS metastatic tumors with known origin, previously classified based on the patient's clinical history and pathological data, as well as a second cohort of resected CNS tumors from 57 patients originally diagnosed as CUP were studied. A qRT‐PCR diagnostic assay that measures the expression level of 48 microRNAs was used to classify the tissue of origin of these metastatic tumors.In this blinded study, the test predictions correctly identified the reference diagnosis of the samples of known origin, excluding samples from prostate origin, in 84% of cases. In the second CUP patient cohort, the test prediction was in agreement with the diagnosis that was later confirmed clinically or with pathological evaluation in 80% of cases.In a cohort of brain and spinal metastases, a previously developed test based on the expression of 48 microRNAs allowed accurate identification of the tumor tissue of origin in the majority of cases. The high accuracy of this test in identifying the tissue of origin of metastases of unknown primary is demonstrated for the first time and may have broad clinical application. | ||
| 700 | 1 | |a Spector, Yael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Edmonston, Tina Bocker |e VerfasserIn |4 aut | |
| 700 | 1 | |a St. Cyr, Brianna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jäger, Diana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lass, Ulrike |e VerfasserIn |0 (DE-588)1167883667 |0 (DE-627)1031403027 |0 (DE-576)511324677 |4 aut | |
| 700 | 1 | |a Aharonov, Ranit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rosenwald, Shai |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chajut, Ayelet |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The oncologist |d Oxford : Oxford University Press, 1996 |g 16(2011), 2 vom: Feb., Seite 165-174 |h Online-Ressource |w (DE-627)32063020X |w (DE-600)2023829-0 |w (DE-576)281196338 |x 1549-490X |7 nnas |a Accurate classification of metastatic brain tumors using a novel microRNA‐based test |
| 773 | 1 | 8 | |g volume:16 |g year:2011 |g number:2 |g month:02 |g pages:165-174 |g extent:10 |a Accurate classification of metastatic brain tumors using a novel microRNA‐based test |
| 856 | 4 | 0 | |u https://doi.org/10.1634/theoncologist.2010-0305 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220908 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1167883667 |a Lass, Ulrike |m 1167883667:Lass, Ulrike |p 6 | ||
| 998 | |g 1075182743 |a Müller, Wolf C. |m 1075182743:Müller, Wolf C. |d 50000 |e 50000PM1075182743 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1816305448 |e 4185957122 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Accurate classification of metastatic brain tumors using a novel microRNA‐based test","title_sort":"Accurate classification of metastatic brain tumors using a novel microRNA‐based test"}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Müller, Wolf C.","given":"Wolf C.","family":"Müller"},{"display":"Spector, Yael","roleDisplay":"VerfasserIn","role":"aut","family":"Spector","given":"Yael"},{"role":"aut","display":"Edmonston, Tina Bocker","roleDisplay":"VerfasserIn","given":"Tina Bocker","family":"Edmonston"},{"role":"aut","display":"St. Cyr, Brianna","roleDisplay":"VerfasserIn","given":"Brianna","family":"St. Cyr"},{"display":"Jäger, Diana","roleDisplay":"VerfasserIn","role":"aut","family":"Jäger","given":"Diana"},{"given":"Ulrike","family":"Lass","role":"aut","roleDisplay":"VerfasserIn","display":"Lass, Ulrike"},{"family":"Aharonov","given":"Ranit","display":"Aharonov, Ranit","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Rosenwald","given":"Shai","display":"Rosenwald, Shai","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Chajut","given":"Ayelet","roleDisplay":"VerfasserIn","display":"Chajut, Ayelet","role":"aut"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 08.09.2022"],"recId":"1816305448","language":["eng"],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"27 January 2011"}],"id":{"doi":["10.1634/theoncologist.2010-0305"],"eki":["1816305448"]},"name":{"displayForm":["Wolf C. Mueller, Yael Spector, Tina Bocker Edmonston, Brianna St. Cyr, Diana Jaeger, Ulrike Lass, Ranit Aharonov, Shai Rosenwald, Ayelet Chajut"]},"physDesc":[{"extent":"10 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2023829-0"],"doi":["10.1002/(ISSN)1549-490X"],"eki":["32063020X"],"issn":["1549-490X"]},"origin":[{"dateIssuedKey":"1996","publisher":"Oxford University Press ; AlphaMed Press ; Wiley","dateIssuedDisp":"1996-","publisherPlace":"Oxford ; Miamisburg, Ohio ; Hoboken, NJ"}],"part":{"year":"2011","issue":"2","pages":"165-174","volume":"16","text":"16(2011), 2 vom: Feb., Seite 165-174","extent":"10"},"pubHistory":["1.1996 -"],"recId":"32063020X","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 19.04.2022"],"disp":"Accurate classification of metastatic brain tumors using a novel microRNA‐based testThe oncologist","title":[{"title_sort":"oncologist","subtitle":"the international peer-reviewed journal for the practicing oncologist, hematologist","title":"The oncologist"}]}]} | ||
| SRT | |a MUELLERWOLACCURATECL2720 | ||