Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets

Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) share a frequent constitutive activation of JAK (Janus kinase)/STAT signaling pathway. Because of complex, nonlinear relations within the pathway, key dynamic properties remained to be identified to predict possible stra...

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Bibliographic Details

Main Authors:	Raia, Valentina (Author) , Schilling, Marcel (Author) , Böhm, Martin (Author) , Hahn, Bettina (Author) , Kowarsch, Andreas (Author) , Raue, Andreas (Author) , Sticht, Carsten (Author) , Bohl, Sebastian (Author) , Saile, Maria (Author) , Möller, Peter (Author) , Gretz, Norbert (Author) , Timmer, Jens (Author) , Theis, Fabian (Author) , Lehmann, Wolf-Dieter (Author) , Lichter, Peter (Author) , Klingmüller, Ursula (Author)
Format:	Article (Journal)
Language:	English
Published:	February 01 2011
In:	Cancer research Year: 2011, Volume: 71, Issue: 3, Pages: 693-704
ISSN:	1538-7445
DOI:	10.1158/0008-5472.CAN-10-2987
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-10-2987
Author Notes:	Valentina Raia, Marcel Schilling, Martin Böhm, Bettina Hahn, Andreas Kowarsch, Andreas Raue, Carsten Sticht, Sebastian Bohl, Maria Saile, Peter Möller, Norbert Gretz, Jens Timmer, Fabian Theis, Wolf-Dieter Lehmann, Peter Lichter, and Ursula Klingmüller